tailieunhanh - Báo cáo y học: "Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity. | Respiratory Research BioMed Central Research Glutathione-S-transferases in lung and sputum specimens effects of smoking and COPD severity Terttu Harju 1 2 Witold Mazur3 Heta Merikallio1 2 Ylermi Soini4 5 and Vuokko L Kinnula3 Address 1Institute of Clinical Medicine Department of Internal Medicine Centre of Excellence in Research P. O. Box 5000 90014 University of Oulu Oulu Finland 2Department of Internal Medicine Clinical Research Center Oulu University Hospital Oulu Finland 3Department of Medicine Division of Pulmonary Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland 4Department of Pathology Oulu University Hospital Oulu Finland and 5Department of Clinical Pathology and Forensic Medicine University of Kuopio Kuopio Finland Email Terttu Harju - Witold Mazur - Heta Merikallio - hmerikal@ Ylermi Soini - msoini@ Vuokko L Kinnula - Corresponding author Open Access Published 13 December 2008 Received 15 September 2008 Respiratory Research 2008 9 80 doi 1465-9921 -9-80 Accepted 13 December 2008 This article is available from http content 9 1 80 2008 Harju et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Oxidative stress plays a potential role in the pathogenesis and progression of chronic obstructive pulmonary disease COPD . Glutathione S-transferases GSTs detoxify toxic compounds in tobacco smoke via glutathione-dependent mechanisms. Little is known about the regulation and expression of GSTs in COPD lung and their presence in airway secretions. Methods GST .

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