tailieunhanh - Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability

There is growing concern about the safety of engineered nanoparticles, which are produced for various industrial applications. Quantum dots are colloidal semiconductor nanoparticles that have unique luminescence char-acteristics and the potential to become attractive tools for medical imaging. However, some of these particles can cause oxidative stress and induce cell death. | ễFEBS Journal Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability Ewa Przybytkowski Maik Behrendt David Dubois and Dusica Maysinger Department of Pharmacology and Therapeutics McGillUniversity Montreal Canada Keywords fat oxidation hypoxia lipid droplets nanoparticles quantum dots Correspondence D. Maysinger Department of Pharmacology and Therapeutics McGillUniversity 3655 Promenade Sir-William-Osler Montreal QC Canada H3G 1Y6 Fax 514 398 6690 Tel 514 398 1264 E-mail Received 5 June 2009 revised 17 August 2009 accepted 24 August 2009 doi There is growing concern about the safety of engineered nanoparticles which are produced for various industrial applications. Quantum dots are colloidal semiconductor nanoparticles that have unique luminescence characteristics and the potential to become attractive tools for medical imaging. However some of these particles can cause oxidative stress and induce cell death. The objective of this study was to explore quantum dot-induced metabolic changes which could occur without any apparent cellular damage. We provide evidence that both uncoated and ZnS-coated quantum dots can induce the accumulation of lipids increase in cytoplasmic lipid droplet formation in two cell culture models glial cells in primary mouse hypothalamic cultures and rat pheochromocytoma PC12 cells. Glial cells treated with CdTe quantum dots accumulated newly synthesized lipids in a phosphoinositide 3-kinase-dependent manner which was consistent with the growth factor-dependent accumulation of lipids in PC12 cells treated with CdTe and CdSe ZnS quantum dots. In PC12 cells quantum dots as well as the hypoxia mimetic CoCl2 induced the up-regulation of hypoxiainducible transcription factor-1a and the down-regulation of the b-oxida-tion of fatty acids both of which could contribute to the accumulation of lipids. On the basis of our results we .

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