tailieunhanh - Transcoronary Transplantation of Progenitor Cells after Myocardial Infarction

Pilot studies suggest that intracoronary transplantation of progenitor cells derived from bone marrow (BMC) or circulating blood (CPC) may improve left ventricular function after acute myocardial infarction. The effects of cell transplantation in patients with healed myocardial infarction are unknown. Methods After an initial pilot trial involving 17 patients, we randomly assigned, in a controlled crossover study, 75 patients with stable ischemic heart disease who had had a myocardial infarction at least 3 months previously to receive either no cell infusion (23 patients) or infusion of CPC (24 patients) or BMC (28 patients) into the patent coronary artery supplying the most dyskinetic left ventricular area | Transcoronary Transplantation of Progenitor Cells after Myocardial Infarction Transcoronary Transplantation of Progenitor Cells after Myocardial Infarction Birgit Assmus . Jorg Honold . Volker Schăchinger . Martina B. Britten . Ulrich Fischer-Rasokat . RalfLehmann . Claudius Teupe . Katrin Pistorius . Hans Martin . Nasreddin D. Abolmaali . Torsten Tonn . Stefanie Dimmeler . and Andreas M. Zeiher . abstract From the Division of Cardiology and Molecular Cardiology Department of Medicine III . . . . . . . . . . Division of Hematology Department of Medicine II . and the Department of Diagnostic and Interventional Radiology . Johann Wolfgang Goethe University and the Institute for Transfusion Medicine and Immunohematology Red Cross Blood Donor Service Baden-Wurttem-berg-Hessen . both in Frankfurt Germany. Address reprint requests to Dr. Zeiher at the Department of Medicine III . Goethe University Theodor-Stern-Kai 7 60590 Frankfurt Germany or at zeiher@. Drs. Assmus and Honold contributed equally to the article. N Engl J Med 2006 355 1222-32. Copyright 2006 Massachusetts Medical Society. background Pilot studies suggest that intracoronary transplantation of progenitor cells derived from bone marrow BMC or circulating blood CPC may improve left ventricular function after acute myocardial infarction. The effects of cell transplantation in patients with healed myocardial infarction are unknown. methods After an initial pilot trial involving 17 patients we randomly assigned in a controlled crossover study 75 patients with stable ischemic heart disease who had had a myocardial infarction at least 3 months previously to receive either no cell infusion 23 patients or infusion of CPC 24 patients or BMC 28 patients into the patent coronary artery supplying the most dyskinetic left ventricular area. The patients in the control group were subsequently randomly assigned to

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