tailieunhanh - Báo cáo hóa học: " Are quantum dots ready for in vivo imaging in human subjects?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Are quantum dots ready for in vivo imaging in human subjects? | Nanoscale Res Lett 2007 2 265-281 DOI s11671-007-9061-9 NANO REVIEW Are quantum dots ready for in vivo imaging in human subjects Weibo Cai Andrew R. Hsu Zi-Bo Li Xiaoyuan Chen Received 14 April 2007 Accepted 24 April 2007 Published online 30 May 2007 to the authors 2007 Abstract Nanotechnology has the potential to profoundly transform the nature of cancer diagnosis and cancer patient management in the future. Over the past decade quantum dots QDs have become one of the fastest growing areas of research in nanotechnology. QDs are fluorescent semiconductor nanoparticles suitable for multiplexed in vitro and in vivo imaging. Numerous studies on QDs have resulted in major advancements in QD surface modification coating biocompatibility sensitivity multiplexing targeting specificity as well as important findings regarding toxicity and applicability. For in vitro applications QDs can be used in place of traditional organic fluorescent dyes in virtually any system outperforming organic dyes in the majority of cases. In vivo targeted tumor imaging with biocompatible QDs has recently become possible in mouse models. With new advances in QD technology such as bioluminescence resonance energy transfer synthesis of smaller size non-Cd based QDs improved surface coating and conjugation and multifunctional probes for multimodality imaging it is likely that human applications of QDs will soon be possible in a clinical setting. Keywords Quantum dot QD Nanoparticles Nanotechnology Cancer Molecular imaging Near-infrared fluorescence NIRF imaging Nanomedicine W. Cai A. R. Hsu . Li X. Chen H The Molecular Imaging Program at Stanford MIPS Department of Radiology and Bio-X Program Stanford University School of Medicine 1201 Welch Rd P095 Stanford CA 94305-5484 USA e-mail shawchen@ Introduction To expedite the clinical application of nanotechnology the National Cancer Institute NCI is currently funding eight Centers of Cancer Nanotechnology Excellence CCNEs and .