tailieunhanh - Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease

Recent trials have demonstrated better outcomes with intensive than with moderate statin treatment. Intensive treatment produced greater reductions in both low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP), suggesting a relationship between these two biomarkers and disease progression. methods We performed intravascular ultrasonography in 502 patients with angiographically documented coronary disease. Patients were randomly assigned to receive moderate treatment (40 mg of pravastatin orally per day) or intensive treatment (80 mg of atorvastatin orally per day) | Statin Therapy LDL Cholesterol C-Reactive Protein and Coronary Artery Disease Statin Therapy LDL Cholesterol C-Reactive Protein and Coronary Artery Disease Steven E. Nissen . E. Murat Tuzcu . Paul Schoenhagen . Tim Crowe . William J. Sasiela . John Tsai . John Orazem . Raymond D. Magorien . Charles O Shaughnessy . and Peter Ganz . for the Reversal of Atherosclerosis with Aggressive Lipid Lowering REVERSAL Investigators abstract background Recent trials have demonstrated better outcomes with intensive than with moderate statin treatment. Intensive treatment produced greater reductions in both low-density lipoprotein LDL cholesterol and C-reactive protein CRP suggesting a relationship between these two biomarkers and disease progression. methods We performed intravascular ultrasonography in 502 patients with angiographically documented coronary disease. Patients were randomly assigned to receive moderate treatment 40 mg ofpravastatin orally per day or intensive treatment 80 mg ofatorvastatin orally per day . Ultrasonography was repeated after 18 months to measure the progression ofatherosclerosis. Lipoprotein and CRP levels were measured at baseline and follow-up. results From the Cleveland Clinic Foundation Cleveland . . . Pfizer New York . . . Ohio State University Medical Center Columbus . North Ohio Heart Care Elyria . and Brigham and Women s Hospital Boston . . Address reprint requests to Dr. Nissen at the Department of Cardiovascular Medicine Cleveland Clinic Foundation 9500 Euclid Ave. Cleveland OH 44195 or at nissens@. The REVERSAL Investigators are listed in the Appendix. N Engl J Med 2005 352 29-38. Copyright 2005 Massachusetts Medical Society. In the group as a whole the mean LDL cholesterol level was reduced from mg per deciliter mmol per liter at baseline to mg per deciliter mmol per liter at 18 months P and the geometric mean CRP level decreased from

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