tailieunhanh - Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women

Few studies have simultaneously investigated the role of soluble tumor necrosis factor a (TNFa ) receptors types 1 and 2 (sTNF-R1 and sTNF-R2), C-reactive protein, and interleukin-6 as predictors of cardiovascular events. The value of these inflammatory markers as independent predictors remains controversial. methods We examined plasma levels of sTNF-R1, sTNF-R2, interleukin-6, and C-reactive protein as markers of risk for coronary heart disease among women participating in the Nurses’ Health Study and men participating in the Health Professionals Follow-up Study in nested case–control analyses | Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women Inflammatory Markers and the Risk ofCoronary Heart Disease in Men and Women Jennifer K. Pai . Tobias Pischon . . Jing Ma . . JoAnn E. Manson . . Susan E. Hankinson . Kaumudi Joshipura . . Gary C. Curhan . . Nader Rifai . Carolyn C. Cannuscio . Meir J. Stampfer . . and Eric B. Rimm . abstract background Few studies have simultaneously investigated the role of soluble tumor necrosis factor a TNF-a receptors types 1 and 2 sTNF-R1 and sTNF-R2 C-reactive protein and interleukin-6 as predictors of cardiovascular events. The value of these inflammatory markers as independent predictors remains controversial. methods We examined plasma levels of sTNF-R1 sTNF-R2 interleukin-6 and C-reactive protein as markers of risk for coronary heart disease among women participating in the Nurses Health Study and men participating in the Health Professionals Follow-up Study in nested case-control analyses. Among participants who provided a blood sample and who were free of cardiovascular disease at baseline 239 women and 265 men had a nonfatal myocardial infarction or fatal coronary heart disease during eight years and six years of follow-up respectively. Using risk-set sampling we selected controls in a 2 1 ratio with matching for age smoking status and date of blood sampling. results After adjustment for matching factors high levels of interleukin-6 and C-reactive protein were significantly related to an increased risk ofcoronary heart disease in both sexes whereas high levels of soluble TNF-a receptors were significant only among women. Further adjustment for lipid and nonlipid factors attenuated all associations only C-reactive protein levels remained significant. The relative risk among all participants was for those with C-reactive protein levels ofat least mg per liter as compared with those with levels ofless than mg per .

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