tailieunhanh - Báo cáo y học: "Systemic lupus erythematosus and its ABCs (APRIL/BLyS complexes)"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Systemic lupus erythematosus and its ABCs (APRIL/BLyS complexes). | Stohl Arthritis Research Therapy 2010 12 111 http content 12 2 111 EDITORIAL L_ Systemic lupus erythematosus and its ABCs APRIL BLyS complexes William Stohl See related research by Dillon etal. http content 12 2 R48 Abstract BLyS and APRIL are closely related members of the TNF ligand superfamily. These cytokines individually may contribute importantly to the development and maintenance of systemic lupus erythematosus SLE . Dillon and colleagues demonstrate that in contrast to most members of the TNF ligand superfamily which form only homotrimers BLyS and APRIL can complex as heterotrimers. These complexes have in vitro biological activity and circulating levels of BLyS APRIL heterotrimers are frequently elevated in SLE but not rheumatoid arthritis patients. Although the mechanism and regulation of heterotrimer formation the interconversion if any between homotrimers and heterotrimers and indeed the normal physiologic role for such heterotrimers remain unknown their preferential overexpression in SLE but not in rheumatoid arthritis raises the possibility that such heterotrimers may be playing a contributory role in SLE. BLyS also commonly known as BAFF and the closely related APRIL are members of the TNF ligand superfamily. These molecules have enjoyed considerable attention from a diverse audience ranging from basic investigators studying B-cell biology to clinical rheumatologists eagerly anticipating and praying for new better medications for their patients with systemic lupus erythematosus SLE . In general individual members of the TNF ligand superfamily are highly parochial. That is they routinely exist in homotrimeric form and thereby exclude other TNF ligand superfamily members from their complex domains. In sharp contrast the recent report by Dillon and colleagues reminds us that BLyS and APRIL can and Correspondence stohl@ Division of Rheumatology Department of Medicine University of Southern .