tailieunhanh - Báo cáo y học: "Increased expression of cardiac IL-17 after burn"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Increased expression of cardiac IL-17 after burn. | Oppeltz et al. Journal of Inflammation 2010 7 38 http content 7 1 38 JOURNAL OF INFLAMMATION RESEARCH Open Access Increased expression of cardiac IL-17 after burn Richard F Oppeltz Qiong Zhang Meenakshi Rani Jennifer R Sasaki Martin G Schwacha Abstract Background Cardiac dysfunction is a common complication associated with major burns. While recent findings have linked the Th-17 T-cell response to the development of autoimmune myocarditis the role of IL-17 and the Th-17 T-cell response in the development of post-burn cardiac dysfunction remains unknown. Methods Male C57BL 6 mice were subjected to a major burn 3rd degree 25 TBSA or sham treatment. Three hours after injury plasma and tissue . heart lung liver small intestine samples were collected and analyzed for the expression of Th-17 cytokine . IL-6 IL-17 IL-22 IL-23 TGF-p levels by ELISA. Results Cardiac tissue levels of the Th-17 cytokines IL-6 IL-17 and IL-22 were significantly elevated at 3 hrs after burn as compared to sham levels. IL-17 was analyzed 1 3 and 7 days after burn and showed a return to baseline levels and without a difference in the burn group. Burn-induced alterations in the level of these cytokines in plasma or other tissues were not evident. The cardiac Th-17 cytokine response after burn injury was specific as cardiac levels of Th-1 IFN-y and Th-2 IL-10 cytokines were not significantly affected after injury. The cardiac Th-17 response correlated with a significant increase in Troponin levels at 3 hr. after burn. Conclusion These findings indicate that early after burn cardiac tissue is associated with significantly elevated levels of Th-17 cytokines. The early Th-17 response after burn appears to be specific for cardiac tissue and may promote myocardial inflammation and dysfunction associated with this form of trauma. Background Burn injury initiates changes in the immune function that result in local and systemic inflammation that can lead to .