tailieunhanh - Báo cáo y học: " Persistent alveolar soft-part sarcoma with liver metastasis: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Persistent alveolar soft-part sarcoma with liver metastasis: a case report. | Silas et al. Journal of Medical Case Reports 2010 4 233 http content 4 1 233 jAg JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Persistent alveolar soft-part sarcoma with liver metastasis a case report 1 2 1 1 1 Olugbenga A Silas Adeyi A Adoga Agabus N Manasseh Godwin O Echejoh Raymond A Vhriterhire Barnabas M Mandong1 Abstract Introduction Alveolar soft-part sarcomas are rare slow-growing tumors that metastasize commonly via vascular routes to the lungs bones lymph nodes and brain causing morbidity and mortality. To the best of our knowledge this is the first case describing metastasis to the liver reported from Nigeria. Case presentation A 57-year-old man of the Urhobo ethnic group of Nigeria presented with a persistent mass in his left calf. It was initially diagnosed as soft-tissue sarcoma and its associated systemic effects lead to his death before a histological diagnosis could be obtained. Conclusions Alveolar soft-part sarcoma with metastasis to the liver can occur in our region northeast Africa and a high index of suspicion is required to make an early diagnosis followed by prompt surgical excision with clear margins in order to prevent mortality. Introduction Alveolar soft-part sarcoma ASPS is an extremely rare vascular soft-tissue sarcoma affecting predominantly adolescents and young adults 1 . Accounting for less than 1 of soft tissue sarcomas ASPS occurs commonly in the lower extremities 44 and the head and neck 27 . Of the head and neck cases 25 occur in the tongue 2 and show a predilection for women. Because it has close clinical and imaging resemblance to common benign vascular tumors such as hemangioma there is danger of misdiagnosis and therefore inadequate or delayed treatment. ASPS often involves the extremities of adolescents and young adults. Although the origin of ASPS is still unknown recent cytogenetic studies revealed chromosomal rearrangements at t X 17 p11 q25 resulting in the ASPL-TFE3 fusion .