tailieunhanh - Báo cáo y học: "New role for Agrin in T cells and its potential importance in immune system regulation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: New role for Agrin in T cells and its potential importance in immune system regulation. | Jury and Kabouridis Arthritis Research Therapy 2010 12 205 http content 12 2 205 REVIEW L_ New role for Agrin in T cells and its potential importance in immune system regulation Elizabeth C Jury 1 and Panagiotis S Kabouridis 2 Abstract Agrin plays a crucial role in the maintenance of the neuromuscular junction. However it is expressed in other tissues as well including T lymphocytes where cell activation induces its expression. Agrin from activated T cells has the capacity to induce aggregation of key receptors and to regulate signalling. Interestingly T cells isolated from patients with systemic lupus erythematosus over-express Agrin and its co-stimulation with the T cell receptor enhances production of pathogenic cytokines. These early studies point to an important function for Agrin in T cell biology and make the case for a more thorough and systematic investigation into its role in the immune system. Introduction Immunity against pathogens and cancer requires cell-cell interactions the type strength and duration of which determine to a large extent the final outcome of the immune response. In this process T cells transiently interact with specialised antigen presenting cells APCs to sample the nature of the prevalent antigens in the body. Recognition of foreign antigen by the T cell receptor TCR results in the strengthening of the T cell-APC interaction which is primarily mediated by an increase in the affinity of integrins for their corresponding ligand in a process known as inside-out signalling 1 . The resulting stable interaction between a T cell and its cognate APC is the formation of a synapse between the two cells generally referred to as the immunological synapse IS 2 owing to its similarity to the neuronal synapse 3 . The strength and duration of cell-cell Correspondence Centre for Rheumatology Royal Free and University College Medical School University College London London W1P .