tailieunhanh - Báo cáo y học: "Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production. | Dixit et al. Journal of Inflammation 2011 8 6 http content 8 1 6 JOURNAL OF INFLAMMATION RESEARCH Open Access Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production 14 1 23 3 3 Vishwa Deep Dixit 1 Hyunwon Yang Khaleel S Sayeed Kim S Stote William V Rumpler David J Baer Dan L Longo1 Mark P Mattson2 Dennis D Taub1 Abstract Background Intermittent fasting IF improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However no studies have evaluated the impact of controlled meal frequency on immune responses in human subjects. Objective A study was conducted to establish the effects of controlled diets with different meal frequencies but similar daily energy intakes on cytokine production in healthy male and female subjects. Design In a crossover study design with an intervening washout period healthy normal weight middle-age male and female subjects n 15 were maintained for 2 months on controlled on-site one meal per day OMD or three meals per day TMD isocaloric diets. Serum samples and peripheral blood mononuclear cells PBMCs culture supernatants from subjects were analyzed for the presence of inflammatory markers using a multiplex assay. Results There were no significant differences in the inflammatory markers in the serum of subjects on the OMD or TMD diets. There was an increase in the capacity of PBMCs to produce cytokines in subjects during the first month on the OMD or TMD diets. Lower levels of TNF-a IL-17 MCP-1 and MIP-1P were produced by PBMCs from subjects on the OMD versus TMD diet. Conclusions PBMCs of subjects on controlled diets exhibit hypersensitivities to cellular stimulation suggesting that stress associated with altered eating behavior might affect cytokine production by immune cells upon stimulation. Moreover stimulated PBMCs derived from healthy individuals on a reduced meal frequency diet .

TÀI LIỆU LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.