tailieunhanh - báo cáo khoa học: " Neuroendocrine carcinoma of the seminal vesicles presenting with Lambert Eaton syndrome: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Neuroendocrine carcinoma of the seminal vesicles presenting with Lambert Eaton syndrome: a case report | Kreiner et al. Journal of Medical Case Reports 2010 4 320 http content 4 1 320 jAc JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Neuroendocrine carcinoma of the seminal vesicles presenting with Lambert Eaton syndrome a case report Benedikt Kreiner Stefan Denzinger Roman Ganzer Hans-Martin Fritsche Maximilian Burger Wolf F Wieland Wolfgang Otto Abstract Introduction Primary tumors of seminal vesicles are rare and only a few cases have been reported. Diagnosis is difficult due to the absence of early clinical signs. Prognosis is generally poor. Case presentation We present the case of a 70-year-old Caucasian man with a seminal vesicle mass and concomitant lymph node metastasis detected by computed tomography and body positron emission tomography low-dose computed tomography scan carried out for evaluation of Lambert Eaton syndrome. Transrectal ultrasound-guided biopsy showed a poorly differented neuroendocrine carcinoma with an immunhistochemical profile similar to small cell lung cancer. Following chemotherapy the disease was stable and active surveillance was initiated. Conclusions Lambert Eaton syndrome may be the initial symptom of a seminal vesicle mass. Diagnosis needs to be obtained by transrectal biopsy and chemotherapy may delay progression of the tumor. Introduction Primary tumors of seminal vesicles are extremely rare. A total of 51 documented cases of seminal vesicle carcinoma in men between the ages of 19 and 90 years old have been reported in the literature 1 . The first case was presented by Lyons in 1925 2 . Epithelial and mesenchymal tumors have been described most often while fibromas myomas and sarcomas are found even less often 3 . Of all seminal vesicle tumors adenocarcinoma is the most prevalent 1 . Primary seminal vesicle tumors have to be clearly distinguished from a neoplasm infiltrating from outside . prostate rectal or bladder cancer. Tumors of seminal vesicle origin must be negative for prostate

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