tailieunhanh - báo cáo khoa học: " Amyotrophic lateral sclerosis-motor neuron disease, monoclonal gammopathy, hyperparathyroidism, and B12 deficiency: case report and review of the literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Amyotrophic lateral sclerosis-motor neuron disease, monoclonal gammopathy, hyperparathyroidism, and B12 deficiency: case report and review of the literature | Rison and Beydoun Journal of Medical Case Reports 2010 4 298 http content 4 1 298 jAg JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Amyotrophic lateral sclerosis-motor neuron disease monoclonal gammopathy hyperparathyroidism and B12 deficiency case report and review of the literature Richard A Rison1 2 Said R Beydoun2 Abstract Introduction Amyotrophic lateral sclerosis the most common form of motor neuron disease is a progressive and devastating disease involving both lower and upper motor neurons typically following a relentless path towards death. Given the gravity of this diagnosis all efforts must be made by the clinician to exclude alternative and more treatable entities. Frequent serology testing involves searching for treatable disorders including vitamin B12 deficiency parathyroid anomalies and monoclonal gammopathies. Case presentation We present the case of a 78-year-old Caucasian man with all three of the aforementioned commonly searched for disorders during an investigation for amyotrophic lateral sclerosis. Conclusions The clinical utility of these common tests and what they ultimately mean in patients with amyotrophic lateral sclerosis is discussed along with a review of the literature. Introduction Amyotrophic lateral sclerosis ALS is a progressive and devastating neurodegenerative disorder that affects primarily motor neurons and is the most common type of motor neuron disorder. Because of the near-uniform kiss of death implications that a diagnosis of ALS carries all efforts must be made to exclude alternative diagnoses. Typical investigations look for any potential treatable cause of the patient s condition. In addition to electrodiagnostic studies the usual investigations include neuroimaging studies to exclude anatomic structural processes such as cervical myelopathies and typical laboratory investigations to search for any potential treatable metabolic abnormality. In particular among the most common .