tailieunhanh - báo cáo khoa học: "Secretion of beta-human chorionic gonadotropin by non-small cell lung cancer: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Secretion of beta-human chorionic gonadotropin by non-small cell lung cancer: a case report | Khattri et al. Journal of Medical Case Reports 2011 5 19 http content 5 1 19 WV journalof medical l rCASE REPORTS CASE REPORT Open Access Secretion of beta-human chorionic gonadotropin by non-small cell lung cancer a case report Saakshi Khattri1 Abhirami Vivekanandarajah1 Seema Varma2 Frank Kong3 Abstract Introduction We describe a case of non-small cell lung cancer that was found to stain positive for beta-human chorionic gonadotropin on immunohistochemistry. Only a few case reports have described lung cancers that secrete beta-human chorionic gonadotropin. Case presentation A 68-year-old Caucasian man presented with symptoms of weakness fatigue and weight loss for the past two months. On examination he was found to have generalized lymphadenopathy and radiologic workup revealed numerous metastases in the lungs liver and kidneys. Biopsy of the supraclavicular lymph node revealed metastatic large cell lung cancer with beta-human chorionic gonadotropin hormone positivity. The serum beta-human chorionic gonadotropin level was 11 286 mIU ml upper limit of normal mIU ml in non-pregnant females . He was diagnosed with stage 4 lung non-small cell lung cancer. The patient refused chemotherapy. He was discharged home with hospice care. Conclusion The markedly elevated serum values of beta-human chorionic gonadotropin initially prompted the medical team to investigate germinal tumors. In the presence of a negative testicular ultrasound workup was performed to find an extratesticular source of the tumor. Finally the diagnosis was made with a tissue biopsy. This case illustrates that atypical markers can be seen in many cancers emphasizing the role of immunohistochemistry and tissue biopsy in establishing the diagnosis. Introduction b-human chorionic gonadotropin b-hCG is commonly produced by germ cell tumors and seldom produced by other tumors. In the literature a few case reports discuss the ectopic production of b-hCG in small cell and .