tailieunhanh - báo cáo khoa học: " Epstein Barr Virus-positive large T-cell lymphoma presenting as acute appendicitis 17 years after cadaveric renal transplant: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Epstein Barr Virus-positive large T-cell lymphoma presenting as acute appendicitis 17 years after cadaveric renal transplant: a case report | Ratuapli et al. Journal of Medical Case Reports 2011 5 5 http content 5 1 5 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Epstein Barr Virus-positive large T-cell lymphoma presenting as acute appendicitis 17 years after cadaveric renal transplant a case report 1 1 2 1 1 Shiva K Ratuapli Shishir Murarka Karen A Miller James C Ferraro Haider Zafar Abstract Introduction The majority of post-transplant lymphoproliferative disorders in renal transplant patients are of the B-cell phenotype while the T-cell phenotype is rare. We report a case of Epstein Barr Virus-positive T-cell lymphoma in a renal transplant patient presenting unusually as acute appendicitis. Case presentation A 45-year-old Hispanic male renal transplant patient presented with right-side abdominal pain 17 years after transplant. The laboratory studies were unremarkable. Laparoscopic exploration showed an inflamed appendix so a laparoscopic appendectomy was performed. Pathology of the appendix showed large cells positive for CD3 CD56 and Epstein Barr Virus-encoded RNA staining and negative for CD20 and CD30. The tissue tested positive for T-cell receptor gene rearrangement by polymerase chain reaction analysis. Treatment management involved reduction of immunosuppression and initiation of chemotherapy with cisplatin etoposide gemcitabine and solumedrol followed by cyclophosphamide hydroxydaunorubicin vincristine and prednisone . He recovered and the allo-grafted kidney is fully functional. Conclusion We report a rare case of post-renal transplant large T-cell lymphoma with an unusual presentation of acute appendicitis and Epstein Barr Virus-positivity which responded well to chemotherapy. Introduction Solid organ transplantation has been increasingly performed in recent years with the use of highly potent immunosuppressive agents to avoid rejection by the host. Post-transplant lymphoproliferative disorders PTLD are well known malignancies found in transplant patients