tailieunhanh - báo cáo khoa học: " Eosinophilic infiltrate in a patient with severe Legionella pneumonia as a levofloxacin-related complication: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Eosinophilic infiltrate in a patient with severe Legionella pneumonia as a levofloxacin-related complication: a case report | Facciolongo et al. Journal of Medical Case Reports 2010 4 360 http content 4 1 360 jAc JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Eosinophilic infiltrate in a patient with severe Legionella pneumonia as a levofloxacin-related complication a case report 1 1 1 2 1 Nicola Facciolongo Francesco Menzella Claudia Castagnetti Alberto Cavazza Roberto Piro Cristiano Carbonelli1 Luigi Zucchi1 Abstract Introduction Legionella pneumonia can appear with different levels of severity and it can often present with complications such as acute respiratory distress syndrome. Case presentation We report the case of a 44-year-old Caucasian man with Legionella pneumonia with successive development of severe acute respiratory distress syndrome. During his stay in intensive care the clinical and radiological situation of the previously observed acute respiratory distress syndrome unexpectedly worsened due to acute pulmonary eosinophilic infiltrate of iatrogenic origin. Conclusion Levofloxacin treatment caused the occurrence of acute eosinophilic infiltrate. Diagnosis was possible following bronchoscopic examination using bronchoaspirate and transbronchial biopsy. Introduction Since the pneumonia epidemic that struck the delegates of the American Legion Convention in Philadelphia in 1976 Legionella spp. has become a relatively frequent cause of community acquired pneumonia 1 . Legionella may appear in different forms from subcli-nical presentations to Legionnaires disease which has a mortality rate as high as 30 to 50 in cases of hospital infections and in cases of complications such as acute respiratory distress syndrome ARDS . The fatality rate is 5 to 25 even in patients who are immunocompetent 2 . Other complications are rare although a significant number of drugs used in the treatment of Legionella pneumonia can be associated with the appearance of pulmonary eosinophilic infiltrates especially non-steroidal anti-inflammatory drugs NSAIDs and

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