tailieunhanh - Báo cáo y học: "Is IgG galactosylation the relevant factor for pregnancy-induced remission of rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Is IgG galactosylation the relevant factor for pregnancy-induced remission of rheumatoid arthritis? | Forger and 0stensen Arthritis Research Therapy 2010 12 108 http content 12 1 108 EDITORIAL Is IgG galactosylation the relevant factor for pregnancy-induced remission of rheumatoid arthritis Frauke Forger and Monika 0stensen See related research by van de Geijn etal. http content 11 6 R193 Abstract During pregnancy most patients with rheumatoid arthritis RA experience spontaneous improvement of their disease activity. Among the soluble candidates that have been investigated in search for the most relevant disease-remitting factor are the galactosylation levels of immunoglobulin G IgG . In RA a higher percentage of IgG lacking the terminal galactose residues thought to play a pro-inflammatory role is found. During pregnancy however IgG galactosylation levels increase and correlate with improved disease activity. The question remains whether the increase in IgG galactosylation during pregnancy is a mere epiphenomenon or a true remission-inducing factor. In a recent issue of Arthritis Research Therapy van de Geijn and colleagues 1 analyse the role of immunoglobulin G IgG galactosylation as a disease-remitting factor in pregnant patients with rheumatoid arthritis RA . The pregnancy-induced improvement of RA has intrigued researchers since the time of Philipp Hench who in searching for the remission-inducing factor discovered cortisone 2 . Unfortunately neither the corticosteroids nor other circulating factors such as sex steroid hormones or a-2 pregnancy-associated globulin proved to be the crucial players that could explain remission of RA in pregnant patients 3-5 . Therefore the search for a factor or a combination of factors able to substantially mitigate symptoms of RA continued. Changes in the percentage of IgG molecules lacking the terminal galactose units in the oligosaccharide chains Correspondence Department of Rheumatology Clinical Immunology and Allergology University Hospital and .