tailieunhanh - Báo cáo y học: "Endothelial cell markers reflecting endothelial cell dysfunction in patients with mixed connective tissue disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Endothelial cell markers reflecting endothelial cell dysfunction in patients with mixed connective tissue disease. | Soltesz et al. Arthritis Research Therapy 2010 12 R78 http content 12 3 R78 RESEARCH ARTICLE Open Access Endothelial cell markers reflecting endothelial cell dysfunction in patients with mixed connective tissue disease Pal Soltesz 1 Daniel Bereczki2 Peter Szodoray3 Maria T Magyar4 Henrietta Der1 Istvan Csipo1 Agota Hajas1 Gyorgy Paragh5 Gyula Szegedi1 and Edit Bodolay 1 Abstract Introduction The aim of the present study was to investigate the association between cardiovascular risk factors and endothelial dysfunction in patients with mixed connective tissue disease MCTD and to determine which biomarkers are associated with atherosclerotic complications such as cardiovascular disease. Methods Fifty MCTD patients and 38 healthy age-matched and sex-matched controls were enrolled in this study. In order to describe endothelial dysfunction we assessed flow-mediated dilation FMD nitrate-mediated dilation NMD and carotid artery intima-media thickness IMT . We investigated FMD of the brachial artery after reactive hyperemia and NMD after sublingual nitroglycerin administration while the IMT of the common carotid artery was determined by ultrasound. Anti-U1 ribonucleoprotein anti-U1RNP antibodies anti-cardiolipin anti-CL antibodies anti-endothelial cell antibody AECA and endothelial cell markers such as soluble thrombomodulin TM and von Willebrand factor antigen vWFAg were assessed. Results The endothelium-dependent vasodilation FMD was significantly impaired in patients with MCTD as compared with controls FMD vs. P while the percentage NMD did not differ NMD vs. P . Mean carotid IMT values were higher in patients than in controls IMT MCTD mm vs. controls mm P . FMD negatively correlated with disease duration the levels of apolipoprotein A1 the paraoxonase-1 activity and systolic blood pressure in MCTD patients. The percentage FMD was significantly lower in MCTD patients with .