tailieunhanh - Báo cáo y học: "Identity of mysterious CD4+CD25–Foxp3+ cells in systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Identity of mysterious CD4+CD25–Foxp3+ cells in systemic lupus erythematosus. | Horwitz Arthritis Research Therapy 2010 12 101 http content 12 1 101 EDITORIAL L_ Identity of mysterious CD4 CD25-Foxp3 cells in systemic lupus erythematosus David A Horwitz See related research by Yang etal. http content 11 5 R153 Abstract Various abnormalities in CD4 CD25 regulatory T cells Tregs in systemic lupus erythematosus SLE include increased Foxp3 cells that are CD25 negative. Barring methodological technical factors these cells could be atypical Tregs or activated non-Treg CD4 cells that express Foxp3. Two groups have reached opposite conclusions that could possibly reflect the subjects studied. One group studied untreated new-onset SLE and suggested that these T cells were mostly CD25-Foxp3 non-Tregs. The other group studied patients with long-standing disease and suggested that these cells are mostly dysfunctional Tregs. A third group reported increased Foxp3 CD4 CD25dim rather than CD25- cells in active SLE and these were also non-Tregs. Thus it is likely that not all Foxp3 T cells in SLE have protective suppressive activity. or CD25- and their identity is poorly defined. Two groups that reported increased percentages of CD4 CD25-Foxp3 cells in SLE have recently tried to characterize these cells but reached different conclusions. A report by Yang and colleagues 1 was recently published in this journal and another by Bonelli and colleagues 2 was published elsewhere. Here we discuss the essence of the controversy and approaches to resolve it. A more complete review of Tregs in SLE has also been published in this journal 3 . The report by Yang and colleagues 1 was preceded by one in which this group studied subjects with untreated new-onset SLE and reported increased percentages of CD4 CD25-Foxp3 cells that were also CD127low 4 . Differences in the intensity of CD127 staining are useful to distinguish CD4 Tregs from CD127bright non-Tregs 5 and suggested that the CD25-Foxp3 cells were Tregs. However .