tailieunhanh - Báo cáo y học: "Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjögren's syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjögren's syndrome. | Available online http content 11 6 R189 Open Access Research article Local expression of tumor necrosis factor-receptor 1 immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjogren s syndrome Jelle L Vosters1 2 Hongen Yin1 Nienke Roescher1 2 Marc R Kok1 2 Paul P Tak2 and John A Chiorini1 Molecular Physiology and Therapeutics Branch National Institute of Dental and Craniofacial Research National Institutes of Health 1 0 Center Drive Bethesda MD 20892 USA 2Division of Clinical Immunology and Rheumatology Academic Medical Center University of Amsterdam Meibergdreef 9 1100 DD Amsterdam The Netherlands Contributed equally Corresponding author John A Chiorini jchiorini@ Received 1 7 Aug 2009 Revisions requested 15 Oct 2009 Revisions received 10 Nov 2009 Accepted 14 Dec 2009 Published 14 Dec 2009 Arthritis Research Therapy 2009 11 R189 doi 86 ar2888 This article is online at http content 11 6 R189 2009 Vosters et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Tumor necrosis factor is a pleiotropic cytokine with potent immune regulatory functions. Although tumor necrosis factor inhibitors have demonstrated great utility in treating other autoimmune diseases such as rheumatoid arthritis there are conflicting results in Sjogren s syndrome. The aim of this study was to assess the effect of a locally expressed tumor necrosis factor inhibitor on the salivary gland function and histopathology in an animal model of Sjogren s syndrome. Methods Using in vivo adeno associated viral gene transfer we have stably expressed soluble tumor necrosis factor-receptor 1-Fc fusion protein locally in the salivary glands in the Non .