tailieunhanh - Báo cáo y học: " Asthma susceptible genes in Chinese population: A meta-analysis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Asthma susceptible genes in Chinese population: A meta-analysis. | Li et al. Respiratory Research 2010 11 129 http content 11 1 129 RESPIRATORY RESEARCH RESEARCH Open Access Asthma susceptible genes in Chinese population A meta-analysis 2 7 sz t2f 3f 4f 5 0 14 4 Xiaobo LI Yonggang Zhang Jie Zhang YUling Xiao Jin Huang can Ilan Chao He Yao Deng Yingying Yang5 Hong Fan2 4 Abstract Background Published data regarding the associations between genetic variants and asthma risk in Chinese population were inconclusive. The aim of this study was to investigate asthma susceptible genes in Chinese population. Methods The authors conducted 18 meta-analyzes for 18 polymorphisms in 13 genes from eighty-two publications. Results Seven polymorphisms were found being associated with risk of asthma namely A Disintegrin and Metalloprotease 33 ADAM33 T1-C T odds ratio OR 95 confidence interval CI AngiotensinConverting Enzyme ACE D 1 OR 95 CI High-affinity IgE receptor b chain FcsRI 3 -6843G A OR 95 CI Interleukin 13 IL-13 -1923C T OR 95 CI IL-13 -2O44A G OR 95 CI Regulated upon Activation Normal T cell Expressed and Secreted RANTES -28C G OR 95 CI Tumor Necrosis Factor-a TNF-a -308G A OR 95 CI . After subgroup analysis by age the ACE D I b2-Adrenergic Receptor b2-AR -79G C TNF-a -308G A Interleukin 4 receptor IL-4R -1902G A and IL-13 -1923C T polymorphisms were found significantly associated with asthma risk in Chinese children. In addition the ACE D I FcsRIb -6843G A TNF-a -308G A IL-13 -1923C T and IL-13 -2044A G polymorphisms were associated with asthma risk in Chinese adults. Conclusion ADAM33 FceRIb RANTES TNF-a ACE b2-AR IL-4R and IL-13 genes could be proposed as asthma susceptible genes in Chinese population. Given the limited number of studies more data are required to validate these associations. Introduction Asthma is one of the most common chronic respiratory diseases affecting about 300 millions of children .

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