tailieunhanh - Báo cáo y học: "α The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: α The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis. | Available online http content 11 6 137 Editorial The role of anti-a-actinin antibodies in the pathogenesis and monitoring of lupus nephritis Pierre Youinou1 and Chaim Putterman2 3 Laboratory of Immunology Brest University Medical School Hospital 2 Avenue Foch BP924 F29609 Brest France 2Division of Rheumatology Albert Einstein College of Medicine Forchheimer 701N 1300 Morris Park Avenue Bronx NY 10461 USA 3Department of Microbiology and Immunology Albert Einstein College of Medicine Forchheimer 701N 1300 Morris Park Avenue Bronx NY 10461 USA Corresponding author Chaim Putterman Published 11 December 2009 Arthritis Research Therapy 2009 11 137 doi ar2869 This article is online at http content 11 6 137 2009 BioMed Central Ltd See related research by Manson et al. http content 11 5 R154 Abstract Antibodies to double-stranded DNA are important in the pathogenesis of nephritis a major clinical manifestation in lupus patients. Since earlier diagnosis of renal involvement may lead to better outcomes identification of the nephritogenic specificity of lupus-associated autoantibodies is important in understanding the disease while monitoring their titer clinically may serve as an improved biomarker. Based upon work in animal models and crosssectional human studies kidney a-actinin was thought to be a plausible cross-reactive target for pathogenic lupus antibodies. Manson and colleagues longitudinally evaluated anti-nucleosome anti-DNA and anti-a-actinin antibodies in 16 lupus patients with new-onset nephritis. While anti-nucleosome and anti-DNA antibody levels were significantly associated and correlated with measures of kidney disease these were not found to be significant with anti-a-actinin antibodies. While in lupus patients the diagnostic use of serum anti-a-actinin antibodies alone or with other novel biomarkers is still under investigation such studies are vital

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