tailieunhanh - Báo cáo y học: "Inflammatory bowel disease serologies in ankylosing spondylitis patients: a pilot study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Inflammatory bowel disease serologies in ankylosing spondylitis patients: a pilot study. | Available online http content 11 6 R177 Research article Inflammatory bowel disease serologies in ankylosing spondylitis patients a pilot study Matthew L Mundwiler1 Ling Mei2 Carol J Landers2 John D Reveille3 Stephan Targan2 and Michael H Weisman2 1Rockford Orthopedic Associates 324 Roxbury Rd Rockford IL 61107 USA 2Center for Inflammatory Bowel Disease Cedars-Sinai Medical Center 8700 Beverly Blvd Los Angeles CA 90048 USA 3Rheumatology University of Texas Health Sciences Center 6431 Fannin Rm 5270 Houston TX 77030 USA Corresponding author Michael H Weisman weisman@ Received 12 Jun 2009 Revisions requested 4 Aug 2009 Revisions received 12 Oct 2009 Accepted 23 Nov 2009 Published 23 Nov 2009 Arthritis Research Therapy 2009 11 R177 doi 86 ar2866 This article is online at http content 11 6 R177 2009 Mundwiler et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Ankylosing spondylitis AS and inflammatory bowel disease IBD share similarities and are classified as spondyloarthropathies. In IBD anti-Saccharomyces cerevisiae antibody ASCA anti-I2 associated with anti-Pseudomonas activity anti-Escherichia coli outer membrane porin C anti-OmpC anti-flagellin anti-CBir1 and antineutrophil cytoplasmic antibodies ANCA possess clinical significance. Because of the overlap between the two conditions a pilot study was designed to compare the frequency of these antibodies in AS patients compared to normal controls. Methods Serum stored from 80 AS patients and 80 control subjects was available for analysis. ASCA anti-I2 anti-OmpC anti-CBir1 and ANCA studies were completed on all serum samples using Enzyme-Linked Immunosorbent Assay ELISA .