tailieunhanh - Báo cáo y học: "Vasculogenesis in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Vasculogenesis in rheumatoid arthritis. | Szekanecz and Koch Arthritis Research Therapy 2010 12 110 http content 12 2 110 EDITORIAL L_ Vasculogenesis in rheumatoid arthritis Zoltán Szekanecz 1 and Alisa E Koch2-3 See related research by Jodon de Villeroché http content 12 1 R27 Abstract Decreased number and impaired functions of endothelial progenitor cells EPCs leading to impaired vasculogenesis have been associated with rheumatoid arthritis RA . Defective vasculogenesis has also been implicated in premature atherosclerosis in RA. Recently early-outgrowth monocytic and late-outgrowth hemangioblastic EPC subsets have been characterized. Hemangioblastic EPCs may exert increased numbers in active RA and may play a role in vascular repair underlying RA. Endothelial progenitor cells EPCs are hematopoietic stem cells expressing CD34 CD 133 type 2 vascular endothelial growth factor VEGF receptor VEGFR-2 or Flk-1 and the CXCR4 chemokine receptor 1-4 . During vasculogenesis EPCs are mobilized from the bone marrow and they differentiate into mature endothelial cells 3 . Under normal conditions vasculogenesis is involved in both prenatal and postnatal tissue development vascular repair and atherosclerosis 2 3 . In rheumatoid arthritis RA several groups have described defective vasculogenesis related to impaired EPC numbers and functions in RA 4-6 . Impaired vasculogenesis has been associated with increased cardiovascular morbidity and mortality in RA 7 8 . Effective antirheumatic therapy such as corticosteroids and tumor necrosis factor-alpha TNF-a blockers may stimulate the outgrowth and function of EPCs and thus may restore defective vasculogenesis in arthritis 5 . In addition as the induction of vasculogenesis may be beneficial for patients with cardiovascular disease 8 the stimulation of EPCs and vasculogenesis may also suppress premature atherosclerosis underlying RA 7 . Correspondence department of Rheumatology .