tailieunhanh - Báo cáo y học: "Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury. | Available online http content 11 6 R172 Research article Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury Huina Zhang1 2 Lin Wang1 Jun Beom Park3 Paul Park1 Victor C Yang3 Scott J Hollister1 2 Frank La Marca1 2 and Chia-Ying Lin1 2 1Spine Research Laboratory Department of Neurosurgery University of Michigan Medical School 1500 E. Medical Center Drive Ann Arbor Michigan 48109 USA 2Department of Biomedical Engineering University of Michigan 2200 Bonisteel Blvd. Ann Arbor Michigan 48109-2099 USA 3Department of Pharmaceutical Sciences College of Pharmacy University of Michigan 428 Church Street Ann Arbor MI 48109-1065 USA Corresponding author Chia-Ying Lin lincy@ Received 24 Jul 2009 Revisions requested 9 Sep 2009 Revisions received 16 Oct 2009 Accepted 13 Nov 2009 Published 13 Nov 2009 Arthritis Research Therapy 2009 11 R172 doi 86 ar2861 This article is online at http content 11 6 R1 72 2009 Zhang et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Earlier work indicates that the cholesterol-lowering drug simvastatin is anabolic to chondrogenic expression of rat intervertebral disc IVD cells which suggests a potential role for simvastatin in IVD regeneration. In this study we expand on our earlier work to test the effectiveness of simvastatin on disc degeneration utilizing a rat tail disc degeneration model. Methods 30 rats that underwent 21 G needle-puncture at rat tail discs were injected with simvastatin-loaded poly ethylene glycol -poly lactic acid-co-glycolic acid -poly ethylene glycol PEG-PLGA-PEG gel 5 mg ml or vehicle control at 4 weeks after needle .