tailieunhanh - Báo cáo y học: "Alterations in the muscle-to-capillary interface in patients with different degrees of chronic obstructive pulmonary disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Alterations in the muscle-to-capillary interface in patients with different degrees of chronic obstructive pulmonary disease. | Eliason et al. Respiratory Research 2010 11 97 http content 11 1 97 RESPIRATORY RESEARCH RESEARCH Open Access Alterations in the muscle-to-capillary interface in patients with different degrees of chronic obstructive pulmonary disease Gabriella Eliason 1 Samy M Abdel-Halim1 2 Karin Piehl-Aulin1 3 and Fawzi Kadi1 Abstract Background It is hypothesized that decreased capillarization of limb skeletal muscle is implicated in the decreased exercise tolerance in COPD patients. We have recently demonstrated decreased number of capillaries per muscle fibre CAF but no changes in CAF in relation to fibre area CAFA which is based on the diffusion distance between the capillary and muscle fibre. The aim of the current study is to investigate the muscle-to-capillary interface which is an important factor involved in oxygen supply to the muscle that has previously been suggested to be a more sensitive marker for changes in the capillary bed compared to CAF and CAFA. Methods 23 COPD patients and 12 age-matched healthy subjects participated in the study. Muscle-to-capillary interface was assessed in muscle biopsies from the tibialis anterior muscle using the following parameters 1 The capillary-to-fibre ratio C Fi which is defined as the sum of the fractional contributions of all capillary contacts around the fibre 2 The ratio between C Fi and the fibre perimeter CFPE-index 3 The ratio between length of capillary and fibre perimeter LC PF which is also referred to as the index of tortuosity. Exercise capacity was determined using the 6-min walking test. Results A positive correlation was found between CFPE-index and ascending disease severity with CFPE-index for type I fibres being significantly lower in patients with moderate and severe COPD. Furthermore a positive correlation was observed between exercise capacity and CFPE-index for both type I and type Ila fibres. Conclusion It can be concluded that the muscle-to-capillary interface is disturbed in the