tailieunhanh - Báo cáo y học: "Genetic and environmental influence on lung function impairment in Swedish twins"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Genetic and environmental influence on lung function impairment in Swedish twins. | Hallberg et al. Respiratory Research 2010 11 92 http content 11 1 92 RESPIRATORY RESEARCH RESEARCH Open Access Genetic and environmental influence on lung function impairment in Swedish twins I o u . u . I I_I s I 1p. 1r2 3 A r 1 r III I I i4h rbi Av k I u . 1 5 h z M V p rN r r f I ỊV IÌ M 6 I lie M i k I A v-. 6 7 Jenny Hallberg Anastasia Iliadou Martin Anderson Maria uernarasson de verdier Ulf Nimen Magnus Dahlback6 Nancy L Pedersen4 Tim Higenbottam8 9 Magnus Svartengren1 Abstract Background The understanding oTthe influence of smoking and sex on lung function and symptoms is important Tor understanding diseases such as COPD. The influence of both genes and environment on lung function smoking behaviour and the presence of respiratory symptoms has previously been demonstrated for each oT these separately. Hence smoking can influence lung function by co-varying not only as an environmental factor but also by shared genetic pathways. Therefore the objective was to evaluate heritability Tor different aspects of lung function and to investigate how the estimates are affected by adjustments Tor smoking and respiratory symptoms. Methods The current study is based on a selected sample of adult twins from the Swedish Twin Registry. Pairs were selected based on background data on smoking and respiratory symptoms collected by telephone interview. Lung function was measured as FEV1 VC and DLco. Pack years were quantified and quantitative genetic analysis was performed on lung function data adjusting stepwise Tor sex pack years and respiratory symptoms. Results Fully adjusted heritability Tor VC was 59 and did not differ by sex with smoking and symptoms explaining only a small part of the total variance. Heritabilities Tor FEV1 and DLco were sex specific. Fully adjusted estimates wereio and 15 in men and 46 and 39 in women respectively. Adjustment Tor smoking and respiratory symptoms altered the estimates differently in men and women. For FEV1 and .