tailieunhanh - Báo cáo y học: "Eotaxin-1 in exhaled breath condensate of stable and unstable asthma patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Eotaxin-1 in exhaled breath condensate of stable and unstable asthma patients. | Zietkowski et al. Respiratory Research 2010 11 110 http content 11 1 110 RESPIRATORY RESEARCH RESEARCH Open Access Eotaxin-1 in exhaled breath condensate of stable and unstable asthma patients Ziemowit Zietkowski1 Maria M Tomasiak-Lozowska1 Roman Skiepko1 Elzbieta Zietkowska2 Anna Bodzenta-Lukaszyk1 Abstract Background Airway eosinophilia is considered a central event in the pathogenesis of asthma. Eotaxin plays a key role in selective eosinophil accumulation in the airways and subsequently their activation and degranulation. The study was undertaken to evaluate eotaxin-1 levels in the exhaled breath condensate EBC of asthmatics with different degrees of asthma severity and to establish the possible correlation of these measurements with other recognized parameters of airway inflammation. Methods EBC was collected from 46 patients with allergic asthma 14 with steroid-naive asthma 16 with ICS-treated stable asthma 16 with ICS-treated unstable asthma and 12 healthy volunteers. Concentrations of eotaxin-1 were measured by ELISA. Results In the three groups of asthmatics eotaxin-1 concentrations in EBC were significantly higher compared with healthy volunteers steroid-naive asthma pg ml stable ICS-treated asthma unstable ICS-treated asthma healthy volunteers . Eotaxin-1 levels were significantly higher in patients with unstable asthma than in the two groups with stable disease. We observed statistically significant correlations between the concentrations of eotaxin-1 in EBC and exhaled nitric oxide FENO or serum eosinophil cationic protein ECP in the three studied groups of asthmatics. We also discovered a significantly positive correlation between eotaxin-1 in EBC and blood eosinophil count in the groups of patients with unstable asthma and steroid-naive asthma. Conclusions Measurements of eotaxin-1 in the EBC of asthma patients may provide another useful diagnostic tool for detecting and monitoring .