tailieunhanh - Báo cáo y học: " Effect of acute hypoxia on respiratory muscle fatigue in healthy humans"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Effect of acute hypoxia on respiratory muscle fatigue in healthy humans. | Verges et al. Respiratory Research 2010 11 109 http content 11 1 109 RESPIRATORY RESEARCH RESEARCH Open Access Effect of acute hypoxia on respiratory muscle fatigue in healthy humans Samuel Verges 1 Damien Bachassont Bernard Wuyam Abstract Background Greater diaphragm fatigue has been reported after hypoxic versus normoxic exercise but whether this is due to increased ventilation and therefore work of breathing or reduced blood oxygenation per se remains unclear. Hence we assessed the effect of different blood oxygenation level on isolated hyperpnoea-induced inspiratory and expiratory muscle fatigue. Methods Twelve healthy males performed three 15-min isocapnic hyperpnoea tests 85 of maximum voluntary ventilation with controlled breathing pattern in normoxic hypoxic SpO2 80 and hyperoxic FiO2 conditions in a random order. Before immediately after and 30 min after hyperpnoea transdiaphragmatic pressure Pdi tw was measured during cervical magnetic stimulation to assess diaphragm contractility and gastric pressure Pga tw was measured during thoracic magnetic stimulation to assess abdominal muscle contractility. Two-way analysis of variance time x condition was used to compare hyperpnoea-induced respiratory muscle fatigue between conditions. Results Hypoxia enhanced hyperpnoea-induced Pdi tw and Pga tw reductions both immediately after hyperpnoea Pdi tw normoxia -22 7 vs hypoxia -34 8 vs hyperoxia -21 8 Pga tw normoxia -17 7 vs hypoxia -26 10 vs hyperoxia -16 11 all P and after 30 min of recovery Pdi tw normoxia -10 7 vs hypoxia -16 8 vs hyperoxia -8 7 Pga tw normoxia -13 6 vs hypoxia -21 9 vs hyperoxia -12 12 all P . No significant difference in Pdi tw or Pga tw reductions was observed between normoxic and hyperoxic conditions. Also heart rate and blood lactate concentration during hyperpnoea were higher in hypoxia compared to normoxia and hyperoxia. Conclusions These results demonstrate that hypoxia exacerbates both diaphragm .

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