tailieunhanh - Báo cáo y học: " Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold. | Eccles et al. Respiratory Research 2010 11 108 http content 11 1 108 RESPIRATORY RESEARCH RESEARCH Open Access Efficacy and safety of an antiviral Iota-Carrageenan nasal spray a randomized double-blind placebo-controlled exploratory study in volunteers with early symptoms of the common cold 1t 2 1 2 2 2 Ron Eccles Christiane Meier Martez Jawad Regina Weinmullner Andreas Grassauer Eva Prieschl-Grassauer Abstract Background The common cold the most prevalent contagious viral disease in humans still lacks a safe and effective antiviral treatment. Iota-Carrageenan is broadly active against respiratory viruses in-vitro and has an excellent safety profile. This study investigated the efficacy and safety of an Iota-Carrageenan nasal spray in patients with common cold symptoms. Methods In a randomized double-blind placebo-controlled exploratory trial 35 human subjects suffering from early symptoms of common cold received Iota-Carrageenan in a saline solution three times daily for 4 days compared to placebo. Results Administration of Iota-Carrageenan nasal spray reduced the symptoms of common cold p and the viral load in nasal lavages p in patients with early symptoms of common cold. Pro-inflammatory mediators FGF-2 Fractalkine GRO G-CSF IL-8 IL-1a IP-10 IL-10 and IFN-a2 were reduced in the Iota-Carrageenan group. Conclusions Iota-Carrageenan nasal spray appears to be a promising treatment for safe and effective treatment of early symptoms of common cold. Larger trials are indicated to confirm the results. Background Common cold is the most prevalent contagious viral disease in humans. It is caused by a variety of viral pathogens with human rhinoviruses HRV being the most abundant ones. Affecting the upper respiratory system symptoms like blocked nose cough and sneezing are most common 1 2 . The socioeconomic losses associated with viral respiratory tract infections however are huge 3 4 with enormous direct and indirect costs for .