tailieunhanh - Báo cáo y học: "Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?. | Volbeda et al. Respiratory Research 2010 11 106 http content 11 1 106 RESPIRATORY RESEARCH RESEARCH Open Access Can AMP induce sputum eosinophils even in subjects with complete asthma remission 1 2 1 2 Franke Volbeda 1 Nick HT ten Hacken Monique E Lodewijk Antoon Dijkstra Machteld N Hylkema M Broekema2 Wim Timens2 Dirkje S Postma1 Abstract Background The definition of clinical asthma remission is based on absence of symptoms and use of medication. However in the majority of these subjects airway inflammation is still present when measured. In the present study we investigated whether complete asthma remission additionally defined by the absence of bronchial hyperresponsiveness BHR and the presence of a normal lung function is associated with the absence of airway inflammation. Methods Patients with a former diagnosis of asthma and a positive histamine provocation test were re-examined to identify subjects with complete asthma remission no asthma symptoms or medication PC20 histamine 32 mg ml FEV1 90 predicted . Patients with PC20 histamine 32 mg ml were defined as current asthmatics and were divided in two groups . asthmatics with and without BHR to adenosine 5 monophoshate AMP . Sputum induction was performed 1 week before and 1 hour after AMP provocation. Sputum induction and AMP provocation were previously shown to be sensitive markers of airway inflammation. Results Seven patients met criteria for complete asthma remission. Twenty-three were current asthmatics including twelve without hyperresponsiveness to AMP. Subjects with complete asthma remission showed no AMP-induced sputum eosinophilia median range 0 - at baseline and 0 - after AMP . After AMP current asthmatics had a significant increase in sputum eosinophils 0 - at baseline and 0 - after AMP as had the subgroup of current asthmatics without hyperresponsiveness to AMP 0 - at baseline and 0 - after AMP . Conclusions .

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