tailieunhanh - Báo cáo y học: "Basement membrane and vascular remodelling in smokers and chronic obstructive pulmonary disease: a cross-sectional study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Basement membrane and vascular remodelling in smokers and chronic obstructive pulmonary disease: a cross-sectional study. | Soltani et al. Respiratory Research 2010 11 105 http content 11 1 105 RESPIRATORY RESEARCH RESEARCH Open Access Basement membrane and vascular remodelling in smokers and chronic obstructive pulmonary disease a cross-sectional study 11 1 112 Amir Soltani David W Reid Sukhwinder S Sohal Richard Wood-Baker Steve Weston H Konrad Muller E Haydn Walters1 Abstract Background Little is known about airway remodelling in bronchial biopsies BB in smokers and chronic obstructive pulmonary disease COPD . We conducted an initial pilot study comparing BB from COPD patients with nonsmoking controls. This pilot study suggested the presence of reticular basement membrane Rbm fragmentation and altered vessel distribution in COPD. Methods To determine whether Rbm fragmentation and altered vessel distribution in BB were specific for COPD we designed a cross-sectional study and stained BB from 19 current smokers and 14 ex-smokers with mild to moderate COPD and compared these to 15 current smokers with normal lung function and 17 healthy and nonsmoking subjects. Results Thickness of the Rbm was not significantly different between groups although in COPD this parameter was quite variable. The Rbm showed fragmentation and splitting in both current smoking groups and ex-smoker COPD compared with healthy nonsmokers p smoking and COPD seemed to have additive effects. Rbm fragmentation correlated with smoking history in COPD but not with age. There were more vessels in the Rbm and fewer vessels in the lamina propria in current smokers compared to healthy nonsmokers p . The number of vessels staining for vascular endothelial growth factor VEGF in the Rbm was higher in both current smoker groups and ex-smoker COPD compared to healthy nonsmokers p . In current smoker COPD VEGF vessel staining correlated with FEV1 predicted r p . Conclusions Airway remodelling in smokers and mild to moderate COPD is associated with fragmentation of the Rbm and .

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