tailieunhanh - Báo cáo y học: " Asthma and gender impact accumulation of T cell subtypes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Asthma and gender impact accumulation of T cell subtypes. | Loza et al. Respiratory Research 2010 11 103 http content 11 1 103 RESPIRATORY RESEARCH RESEARCH Open Access Asthma and gender impact accumulation of T cell subtypes Matthew J Loza Susan Foster Eugene R Bleecker Stephen P Peters Raymond B Penn Abstract Background The Th2 hypothesis for asthma asserts that an increased ratio of Th2 Th1 cytokine production plays an important pathogenic role in asthma. Although widely embraced the hypothesis has been challenged by various empirical observations and has been described as overly simplistic. We sought to establish whether CD3 CD28-mediated and antigen-independent accumulation of type 1 and type 2 T cells differs significantly between nonasthmatic and asthmatic populations. Methods An ex vivo system was used to characterize the regulation of IFN-g-producing type 1 and IL-13-producing type 2 T cell accumulation in response to CD3 CD28 and IL-2 stimulation by flow cytometry. Results IL-13-producing T cells increased in greater numbers in response to antigen-independent stimulation in peripheral blood lymphocytes from female atopic asthmatic subjects compared with male asthmatics and both male and female atopic non-asthmatic subjects. IFN-g T cells increased in greater numbers in response to either antigen-independent or CD3 CD28-mediated stimulation in peripheral blood lymphocytes from atopic asthmatic subjects compared to non-asthmatic subjects regardless of gender. Conclusions We demonstrate that T cells from asthmatics are programmed for increased accumulation of both type 2 and type 1 T cells. Gender had a profound effect on the regulation of type 2 T cells thus providing a mechanism for the higher frequency of adult asthma in females. Background Asthma is frequently labeled a Th2-like disorder based on an inflammatory profile in the asthmatic airway and is characterized by preferential elaboration of Th2 T cells and their cytokines 1-3 . After allergen challenge elevated levels of the type 2 .