tailieunhanh - Báo cáo y học: "The role of pleiotrophin and β-catenin in fetal lung development"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"The role of pleiotrophin and β-catenin in fetal lung development. | Weng and Liu Respiratory Research 2010 11 80 http content 11 1 80 RESPIRATORY RESEARCH REVIEW Open Access The role of pleiotrophin and p-catenin in fetal lung development Tingting Weng and Lin Liu Abstract Mammalian lung development is a complex biological process which is temporally and spatially regulated by growth factors hormones and extracellular matrix proteins. Abnormal changes of these molecules often lead to impaired lung development and thus pulmonary diseases. Epithelial-mesenchymal interactions are crucial for fetal lung development. This paper reviews two interconnected pathways pleiotrophin and Wnt p-catenin which are involved in fibroblast and epithelial cell communication during fetal lung development. 1. Fetal lung development Stages of fetal lung development Fetal lung development is a complex biological process which involves temporal and spatial regulation of multiple factors such as growth factors transcriptional factors and extracellular matrix ECM . The development of the intimate relationship between airways and blood vessels is crucial for the normal lung function. Morphologically mouse lung development can be divided into 5 stages i Embryonic Stage E9 to in which lung buds originate as an outgrowth from the ventral wall of the foregut where lobar division occurs ii Pseudoglandular Stage to in which conducting epithelial tubes surrounded by thick mesenchyme are formed distinguished by extensive airway branching iii Canalicular stage to in which bronchioles are produced characterized by an increasing number of capillaries in close contact with cuboidal epithelium and the beginning of alveolar epithelium development iv Saccular Stage to PN5 in which alveolar ducts and air sacs are developed and v Alveolar Stage PN5 to PN28 in which secondary septation occurs defined by a marked increase of the number and size of capillaries and alveoli 1 . Recently a new model of lung branching

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