tailieunhanh - Báo cáo y học: " Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE study. | Singh et al. Respiratory Research 2010 11 77 http content 11 1 77 RESPIRATORY RESEARCH RESEARCH Open Access Sputum neutrophils as a biomarker in COPD findings from the ECLIPSE study Dave Singh 1 Lisa Edwards2 Ruth Tal-Singer3 and Stephen Rennard4 Abstract Introduction The percentage of neutrophils in sputum are increased in COPD patients and may therefore be a biomarker of airway inflammation. We studied the relationships between sputum neutrophils and FEV1 health status exacerbation rates systemic inflammation and emphysema and long term variability at 1 year. Methods Sputum samples were obtained from 488 COPD patients within the ECLIPSE cohort. 359 samples were obtained at baseline and 297 after 1 year. 168 subjects provided samples at both visits. Serum interleukin-6 IL-6 IL-8 surfactant protein D and C-reactive protein levels were measured by immunoassays. Low-dose CT scans evaluated emphysema. Results Sputum neutrophil increased with GOLD stage. There was a weak association between sputum neutrophils and FEV1 predicted univariate r2 and at baseline and year 1 respectively p after multivariate regression . Similar weak but significant associations were observed between neutrophil and health status measured using the St Georges Respiratory Questionairre. There were no associations between neutrophils and exacerbation rates or emphysema. Associations between sputum neutrophils and systemic biomarkers were nonsignificant or similarly weak. The mean change over 1 year in neutrophil was an increase of . Conclusions Sputum neutrophil measurements in COPD are associated weakly with FEV1 predicted and health status. Sputum neutrophil measurements were dissociated from exacerbation rates emphysema and systemic inflammation. Introduction Chronic obstructive pulmonary disease COPD is a progressive inflammatory airway disease the most important cause of which is cigarette smoking. COPD is characterised by persistent and .