tailieunhanh - Báo cáo y học: " Prospective cohort studies on risk factors for cardiovascular events in systemic lupus erythematosus: a major challenge"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Prospective cohort studies on risk factors for cardiovascular events in systemic lupus erythematosus: a major challenge. | Bultink Arthritis Research Therapy 2010 12 107 http content 12 1 107 EDITORIAL Prospective cohort studies on risk factors for cardiovascular events in systemic lupus erythematosus a major challenge Irene EM Bultink See related research by Gustafsson etal. http content 11 6 R186 Abstract Cardiovascular disease CVD has been identified as a major contributor to morbidity and mortality in patients with systemic lupus erythematosus SLE . The etiology of premature CVD in SLE is supposed to have many factors including traditional coronary artery disease CAD risk factors antiphospholipid antibodies and metabolic and inflammatory factors. Despite the overwhelming interest in CVD in SLE research prospective studies evaluating risk factors for hard endpoints that is cardiovascular events are relatively scarce. The article by Gustafsson and colleagues suggests that prothrombotic factors play an important role in SLE-related CVD and that the influence of traditional CAD risk factors might be limited. In a recent issue of Arthritis Research Therapy Gustaf-sson and colleagues 1 presented the results of an interesting prospective study on risk factors for cardiovascular events CVEs in 182 Swedish patients with systemic lupus erythematosus SLE who were selected to be free of CVEs at inclusion. In contrast to the numerous cross-sectional studies and research on surrogate markers of cardiovascular disease CVD performed relatively few prospective studies on predictors of CVEs in SLE have been published 2-4 . In the present study age presence of any antiphospholipid antibody aPL von Willebrand factor vWf and absence of thrombocytopenia were independent predictors of the first CVE. Correspondence Department of Rheumatology VU University Medical Center PO Box 7057 1007 MB Amsterdam The Netherlands 2 BioMed Central 2010 BioMed Central Ltd The study demonstrates the difficulties inherent in research of events in which the .