tailieunhanh - Báo cáo y học: " Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function. | Neveu et al. Respiratory Research 2010 11 28 http content 11 1 28 RESPIRATORY RESEARCH RESEARCH Open Access Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function 12 2 2 2 Wendy A Neveu Jenna L Allard Danielle M Raymond Lorraine M Bourassa Stephanie M Burns Janice Y Bunn3 Charles G Irvin2 David A Kaminsky2 Mercedes Rincon1 Abstract Background Asthma is a chronic inflammatory disease of the airway that is characterized by a Th2-type of immune response with increasing evidence for involvement of Th17 cells. The role of IL-6 in promoting effector T cell subsets suggest that IL-6 may play a functional role in asthma. Classically IL-6 has been viewed as an inflammatory marker along with TNFa and IL-1Ị3 rather than as regulatory cytokine. Objective To investigate the potential relationship between IL-6 and other proinflammatory cytokines Th2 Th17 cytokines and lung function in allergic asthma and thus evaluate the potential role of IL-6 in this disease. Methods Cytokine levels in induced sputum and lung function were measured in 16 healthy control and 18 mild-moderate allergic asthmatic subjects. Results The levels of the proinflammatory biomarkers TNFa and IL-1P were not different between the control and asthmatic group. In contrast IL-6 levels were specifically elevated in asthmatic subjects compared with healthy controls p . Hierarchical regression analysis in the total study cohort indicates that the relationship between asthma and lung function could be mediated by IL-6. Among Th2 cytokines only IL-13 p was also elevated in the asthmatic group and positively correlated with IL-6 levels rS p . Conclusions In mild-moderate asthma IL-6 dissociates from other proinflammatory biomarkers but correlates with IL-13 levels. Furthermore IL-6 may contribute to impaired lung function in allergic asthma. Background Asthma is a chronic inflammatory disease .