tailieunhanh - Báo cáo y học: " Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients. | Grunewald et al. Respiratory Research 2010 11 25 http content 11 1 25 RESPIRATORY RESEARCH RESEARCH Open Access Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients I z-s. I . s U Cri I XI A r-s I I I 5D I D r s 12 5 D J V I I I s VI I z t Fz 3 5 ft Ị U I ir l lir - ll l 5 rnpi A r I r V11 I d4 5 I I_I i I I - r-f-2 5 Johan Grunewaid Boei Brynedai Perniiia Darlington Magnus Niseii Kerstin Cederiund Jan Hiiiert Anders Ekiund1 5 Abstract Background A strong genetic influence by the MHC ciass II region has been reported in sarcoidosis however in many studies with different resuits. This may possibiy be caused by actuai differences between distinct ethnic groups too smaii sampie sizes or because of iack of accurate ciinicai subgrouping. Subjects and methods In this study we HLA typed a iarge patient popuiation n 754 recruited from one singie centre. Patients were sub-grouped into those with Lofgren s syndrome LS n 302 and those without nonLofgren s n 452 and the majority of them were ciinicaiiy ciassified into those with recovery within two years resoiving and those with signs of disease for more than two years non-resoiving . PCR was used for determination of HLA-DRB1 aiieies. Swedish heaithy biood donors n 1366 served as controis. Results There was a dramatic difference in the distribution of HLA aiieies in LS compared to non-LS patients p 4 X 10-36 . Most notabiy DRB1 01 DRB1 03 and DRB1 14 cieariy differed in LS and non-LS patients. In reiation to disease course DRB1 07 DRB1 14 and DRB1 15 generaiiy associated with whiie DRB1 01 and DRB1 03 protected against a non-resoiving disease. Interestingiy the ciinicai infiuence of DRB1 03 good prognosis dominated over that of DRB1 15 bad prognosis . Conclusions We found severai significant differences between LS and non-LS patients and we therefore suggest that genetic association studies in sarcoidosis shouid inciude a carefui ciinicai characterisation and