tailieunhanh - Báo cáo y học: "MMP-9 gene variants increase the risk for non-atopic asthma in children"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:MMP-9 gene variants increase the risk for non-atopic asthma in children. | Pinto et al. Respiratory Research 2010 11 23 http content 11 1 23 RESPIRATORY RESEARCH RESEARCH Open Access MMP-9 gene variants increase the risk for non-atopic asthma in children 12 3 3 4 2 Leonardo A Pinto Martin Depner Norman Klopp Thomas Illig Christian Vogelberg Erika von Mutius Michael Kabesch5 Abstract Background Atopic and non-atopic wheezing may be caused by different etiologies while eosinophils are more important in atopic asthmatic wheezers neutrophils are predominantly found in BAL samples of young children with wheezing. Both neutrophils as well as eosinophils may secrete matrix metalloproteinase 9 MMP-9 . Considering that MMP-9 plays an important role in airway wall thickening and airway inflammation it may influence the development of obstructive airway phenotypes in children. In the present study we investigated whether genetic variations in MMP-9 influence the development of different forms of childhood asthma. Methods Genotyping of four HapMap derived tagging SNPs in the MMP-9 gene was performed using MALDI-TOF MS in three cross sectional study populations of German children age 9-11 N 4 264 phenotyped for asthma and atopic diseases according to ISAAC standard procedures. Effects of single SNPs and haplotypes were studied using SAS and Haploview. Results SNP rs2664538 significantly increased the risk for non-atopic wheezing OR 95 CI p and non-atopic asthma OR 95 CI p . Furthermore the minor allele of rs3918241 may be associated with decreased expiratory flow measurements in non-atopic children. No significant effects on the development of atopy or total serum IgE levels were observed. Conclusions Our results have shown that homozygocity for MMP-9 variants increase the risk to develop nonatopic forms of asthma and wheezing which may be explained by a functional role of MMP-9 in airway remodeling. These results suggest that different wheezing disorders in childhood are .