tailieunhanh - Báo cáo y học: "Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder. | Lin et al. Respiratory Research 2010 11 53 http content 11 1 53 RESPIRATORY RESEARCH RESEARCH Open Access Cigarette smoking cadmium exposure and zinc intake on obstructive lung disorder Yu-Sheng Lin1 James L Caffrey2 Man-Huei Chang3 Nicole Dowling3 and Jou-Wei Lin 4 5 Abstract Background and objective This study examined whether zinc intake was associated with lower risk of smoking-induced obstructive lung disorder through interplay with cadmium one of major toxicants in cigarette smoke. Methods Data were obtained from a sample of 6 726 subjects aged 40 from the Third National Health and Nutrition Examination Survey. The forced expiratory volume in 1 second FEV1 and forced vital capacity FVC were measured using spirometry. Gender- ethnicity- and age-specific equations were used to calculate the lower limit of normal LLN to define obstructive lung disorder as observed FEV1 FVC ratio and FEV1 below respective LLN. Zinc intake was assessed by questionnaire. Logistic regression analysis was applied to investigate the associations of interest. Results The analyses showed that an increased prevalence of obstructive lung disorder was observed among individuals with low zinc intake regardless of smoking status. The adjusted odds of lung disorder are approximately times greater for subjects in the lowest zinc-intake tertile than those in the highest tertile odds ratio 95 confidence interval . The effect of smoking on lung function decreased considerably after adjusting for urinary cadmium. Protective association between the zinc-to-cadmium ratio log-transformed and respiratory risk suggests that zinc may play a role in smoking-associated lung disorder by modifying the influence of cadmium. Conclusions While zinc intake is associated with lower risk of obstructive lung disorder the role of smoking cession and or prevention are likely to be more important given their far greater effect on respiratory risk. Future research is .