tailieunhanh - Báo cáo y học: "Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable?. | Selby et al. Respiratory Research 2010 11 43 http content 11 1 43 RESPIRATORY RESEARCH RESEARCH Open Access Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable Anna Selby 1 Bernie Clayton2 Jane Grundy2 Katy Pike1 Kirsty Drew3 Abid Raza2 Ramesh Kurukulaaratchy1 2 3 S Hasan Arshad1 2 3 and Graham Roberts 1 2 3 Abstract Background Exhaled nitric oxide is a non-invasive marker of airway inflammation and a portable analyser the NIOX MINO Aerocrine AB Solna Sweden is now available. This study aimed to assess the reproducibility of the NIOX MINO measurements across age sex and lung function for both absolute and categorical exhaled nitric oxide values in two distinct groups of children and teenagers. Methods Paired exhaled nitric oxide readings were obtained from 494 teenagers aged 16-18 years enrolled in an unselected birth cohort and 65 young people aged 6-17 years with asthma enrolled in an interventional asthma management study. Results The birth cohort participants showed a high degree of variability between first and second exhaled nitric oxide readings mean intra-participant difference ppb 95 limits of agreement to ppb although there was very close agreement when values were categorised as low normal intermediate or high kappa p . Similar findings were seen in subgroup analyses by sex lung function and asthma status. Similar findings were seen in the interventional study participants. Conclusions The reproducibility of exhaled nitric oxide is poor for absolute values but acceptable when values are categorised as low normal intermediate or high in children and teenagers. One measurement is therefore sufficient when using categorical exhaled nitric oxide values to direct asthma management but a mean of at least two measurements is required for absolute values. Introduction Asthma is a chronic inflammatory disorder of the airways associated with airway hyperresponsiveness and recurrent .

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