tailieunhanh - Báo cáo y học: "Iron deposition and increased alveolar septal capillary density in nonfibrotic lung tissue are associated with "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Iron deposition and increased alveolar septal capillary density in nonfibrotic lung tissue are associated with. | Kim et al. Respiratory Research 2010 11 37 http content 11 1 37 RESPIRATORY RESEARCH RESEARCH Open Access Iron deposition and increased alveolar septal capillary density in nonfibrotic lung tissue are associated with pulmonary hypertension in idiopathic pulmonary fibrosis Kyung-Hee Kim1 Fabien Maldonado2 Jay H Ryu2 Patrick W Eiken3 Thomas E Hartman3 Brian J Bartholmai3 Paul A Decker4 and Eunhee S Yi 5 Abstract Background Early diagnosis of pulmonary hypertension PH in idiopathic pulmonary fibrosis IPF has potential prognostic and therapeutic implications but can be difficult due to the lack of specific clinical manifestations or accurate non-invasive tests. Histopathologic parameters correlating with PH in IPF are also not known. Remodeling of postcapillary pulmonary vessels has been reported in the nonfibrotic areas of explanted lungs from IPF patients. We hypothesized that iron deposition and increased alveolar capillaries the findings often seen in postcapillary PH might predict the presence of clinical PH independent of the severity of fibrosis or ventilatory dysfunction in IPF patients. To test this hypothesis we examined the association between these histologic parameters and the degree of PH with consideration of the severity of disease in IPF. Methods Iron deposition and alveolar septal capillary density ASCD were evaluated on histologic sections with hematoxylin-eosin iron elastin and CD34 stainings. Percentage of predicted forced vital capacity FVC was used for grading pulmonary function status. Fibrosis score assessed on high resolution computed tomography HRCT was used for evaluating overall degree of fibrosis in whole lungs. Right ventricular systolic pressure RVSP by transthoracic echocardiography was used for the estimation of PH. Univariate and multivariate regression analyses were performed. Results A cohort of 154 patients was studied who had the clinicopathological diagnosis of IPF with surgical lung biopsies or explants