tailieunhanh - Draft Report on Alternative (Non-Animal) Methods for Cosmetics Testing: current status and future prospects – 2010

Mobilizing the resources to reach the ICPD and MDG target of universal access to reproductive health by 2015 is essential if international development goals are to be realized. The challenge before the international community – donors and developing countries alike – is to move from declarations of good intentions to active partnerships and investments in a healthier future. This book provides an abundance of easy-to-access information that can be helpful in building the case for increased resources. In this regard, it may be helpful to recall that the ICPD Programme of Action contained global estimates of resource requirements for the implementation of national population and reproductive health programmes through 2015. Approximately. | Working Group 5 Reproductive Toxicity DRAFT FOR CONSULTATION 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 Draft Report on Alternative Non-Animal Methods for Cosmetics Testing current status and future prospects - 2010 Chapter 5 Reproductive Toxicity . Compiled by Workgroup 5 14 July 2010 Qoroh A rl Z W1 Io c Rmcphord2 Qnconno Rrornor3 VÍ111Ỉ114 TidGtnn5 Sarah . Adler A Iioinas Brosciiard Susanne Dreiner lYAark. Cronin Gj-eorge as ton Elise Grignard3 Aldert Piersma6 Guillermo Repetto7 and Michael Schwarz8 Centre for Documentation and Evaluation of Alternatives to Animal Experiments ZEBET Federal Institute for Risk Assessment BfR Berlin Germany 2Merck KGaA Darmstadt Germany 3Institute for Health Consumer Protection Joint Research Centre European Commission Ispra Italy .ỊỊ 4School of Pharmacy and Chemistry Liverpool John Moores University Liverpool England 5Miami Valley Innovation Center The Procter and Gamble Company Cincinnati USA 6Laboratory for Health Protection Research National Institute for Public Health and the Environment RIVM Bilthoven The Netherlands National Institute of Toxicology and Forensic Sciences University Pablo de Olavide Sevilla Spain institute of Pharmacology und Toxicology University of Tuebingen Germany 1 Working Group 5 Reproductive Toxicity DRAFT FOR CONSULTATION 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 1. Executive Summary In the last decades significant efforts have been undertaken to develop alternative methods to assess reproductive toxicity. However despite the impressive number of alternative tests that have been published and are listed in this report the majority of these tests have not yet gained regulatory acceptance. There are a number of reasons for the relatively slow progress in the implementation of alternative methods for reproductive toxicity safety evaluations these include the lengthy research and

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