tailieunhanh - Essential Urology - part 5

Pheochromocytoma của tủy thượng thận có thể được đánh giá sau khi tiêm meta-iodobenzylguanidine (mIBG), được thực hiện bởi các tế bào thần kinh adrenergic. MIBG cũng đánh dấu phóng xạ iodine-131 cho máy ảnh gamma cho hình ảnh tủy thượng thận và mô adrenergic endocrinologically hoạt động khác | 88 Richman and Resnick hyperproduction of cortical steroids by a functional tumor will be seen with gamma camera imaging. Pheochromocytoma of the adrenal medulla can be evaluated after the injection of meta-iodobenzylguanidine MIBG which is taken up by adrenergic neurons. MIBG is also radiolabeled with iodine-131 for the gamma camera to image the adrenal medulla and any other endocrinologically active adrenergic tissues. This is especially useful when a patient has biochemical evidence of a pheochromocytoma but no obvious adrenal mass on CT scan. MIBG scanning is very sensitive and specific for localizing intra-adrenal and extra-adrenal pheochromocytoma and neuroblastoma. Prostate Creating radiolabeled monoclonal antibodies MAb to tumor antigens allows cancerspecific radionuclide imaging. This is the mechanism of Prostascint imaging which uses indium-111 labeled capromab pendetide. Capromab is a MAb against prostate-specific membrane antigen found only on the surface of prostate cells. After intravenous injection of the tracer the patient is immediately imaged with the gamma camera. This is to assess blood pool distribution of the capromab. The patient is then reimaged 4 to 7 d later revealing areas of the body with prostate tissue. This study is most useful when evaluating a patient with a rising prostate-specific antigen after radical prostatectomy. Tracer may be seen in the prostatic bed with local recurrence or in the pelvic lymph nodes or other metastatic sites with advanced disease. Bone Scan Radionuclide imaging of the skeletal system is important in staging known genitourinary malignancies especially prostate cancer. Bone scintigraphy is performed with tech-netium-99m-labeled methylene diphosphonate. The tracer is taken up into bone crystals and the amount of tracer the bone takes up depends on how vascular the bone is. Bone involved with metastatic tumors or inflammation tends to be hyper-vascular and takes up more tracer. This produces hot areas when .

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