tailieunhanh - Predictors of treatment failure among pulmonary tuberculosis patients in Mulago hospital, Uganda

Introduction: Early identification of Tuberculosis (TB) treatment failure using cost effective means is urgently needed in developing nations. The study set out to describe affordable predictors of TB treatment failure in an African setting. Objective: To determine the predictors of treatment failure among patients with sputum smear positive pulmonary TB at Mulago hospital. The study was carried out in the TB clinic of Mulago hospital Kampala, Uganda. This was an unmatched case control study where fifty patients with a diagnosis of TB treatment failure (cases) and 100 patients declared cured after completing anti TB treatment (controls) were recruited into the study. Cases were compared with controls. | Predictors of treatment failure among pulmonary tuberculosis patients in Mulago hospital Uganda Namukwaya E1 Nakwagala FN 1 Mulekya F2 Mayanja-Kizza H 1 Mugerwa R1 1. Department of Medicine College of Health Sciences Makerere University Kampala Uganda. 2. School of Public Health Makerere University Kampala Uganda. Abstract Introduction Early identification of Tuberculosis TB treatment failure using cost effective means is urgently needed in developing nations. The study set out to describe affordable predictors of TB treatment failure in an African setting. Objective To determine the predictors of treatment failure among patients with sputum smear positive pulmonary TB at Mulago hospital. The study was carried out in the TB clinic of Mulago hospital Kampala Uganda. This was an unmatched case control study where fifty patients with a diagnosis of TB treatment failure cases and 100 patients declared cured after completing anti TB treatment controls were recruited into the study. Cases were compared with controls to determine predictors of treatment failure. Results Significant predictors of treatment failure in this study included a positive sputum smear at 2 months of TB treatment OR 95 CI and poor adherence to anti TB treatment OR 95 CI . Conclusion This study identified a treatment related and a simple laboratory predictor of TB treatment failure in Mulago hospital which may be used in resource limited settings for early recognition of those at risk and early intervention. Key words Predictors Treatment failure Pulmonary TB African Health Sciences 2011 11 S1 S105 S111 Introduction The control of tuberculosis TB remains a challenge globally 1 2 more so in sub-Saharan Africa2 and in high burden countries like Uganda where treatment target goals have not yet been For TB control the highest priority is to detect at least 70 of the sputum smear positive cases and to cure at least 85 of the sputum smear positive cases. If these .