tailieunhanh - PREVALENCE OF INITIAL DRUG RESISTANCE AMONG PATIENTS ATTENDING THE CLINICS IN MADRAS CITY

Fairly large proportion of patients attending for the first time the Chest Clinics in India have had anti-tuberculosis chemotherapy for some time though irregularly. The assessment of the prevalence of Initial Drug Resistance (IDR) among these patients will be of great value in their management and also in formulating general policies of treatment in the Chest Clinics under the National Tuberculosis Control Programme. Material and Methods Chest symptomatics attending for the first time at the five Chest Clinics located in different parts of Madras City, over a period of three months, from 1st March 1982 till the end of May 1982, were investigated, irrespective of whether they had previous chemotherapy or not. A preliminary skiagram of the chest. | Ind. J. Tub. 1984 31 164 PREVALENCE OF INITIAL DRUG RESISTANCE AMONG PATIENTS ATTENDING THE CLINICS IN MADRAS CITY . KRISHNASWAMI R. VENKATESAN AND R. PARTHASARATHY Summary Sputum culture of 803 smear positive peases of pulmonary tuberculosis attending for the first time at the five Chest Clinics located in different parts of Madras was positive m 750. These were further subjected to drug sensitivity tests cultures were resistant to one drug to two drugs and to three drugs giving a total initial drug resistance of 45 . Total initial resistance to Isoniazid was significantly higher than for any other drug. In the case of Ethambutol and Streptomycin it was and respectively. Total initial resistance to Rifampicin was found to be the lowest as compared to all other drugs. Introduction Fairly large proportion of patients attending for the first time the Chest Clinics in India have had anti-tuberculosis chemotherapy for some time though irregularly. The assessment of the prevalence of Initial Drug Resistance IDR among these patients will be of great value in their management and also in formulating general policies of treatment in the Chest Clinics under the National Tuberculosis Control Programme. Material and Methods Chest symptomatics attending for the first time at the five Chest Clinics located in different parts of Madras City over a period of three months from 1st March 1982 till the end of May 1982 were investigated irrespective of whether they had previous chemotherapy or not. A preliminary skiagram of the chest was taken and those with suggestive pulmonary shadows were subjected to detailed bacteriological investigations commencing with sputum smears. Two spot and one overnight sputum specimens were examined for Acid Fast Bacilli by Ziehl Neelsen procedure. For all the sputum smear positive cases culture for M. Tuberculosis and drug sensitivity tests were carried out. Culture The technique adopted for culture of M. Tuberculosis .