tailieunhanh - Breath biomarkers of active pulmonary tuberculosis

Volatile organic compounds (VOCs) in breath may contain biomarkers of active pulmonary tuberculosis derived from the infectious organism (metabolites of Mycobacterium tuberculosis) and from the infected host (products of oxidative stress). Methods: We analyzed breath VOCs in 226 symptomatic high-risk patients in USA, Philippines, and UK, using gas chromatography/mass spectroscopy. Diagnosis of disease was based on sputum culture, smear microscopy, chest radiography and clinical suspicion of tuberculosis (CSTB). Chromatograms were converted to a series of 8 s overlapping time slices. Biomarkers of active pulmonary tuberculosis were identified with a Monte Carlo analysis of time-slice alveolar gradients (abundance in breath minus abundance in room air) | ARTICLE IN PRESS Tuberculosis xxx 2010 1-7 Contents lists available at ScienceDirect Tuberculosis journal homepage http journals tube Tuberculosis DIAGNOSTICS Breath biomarkers of active pulmonary tuberculosis Michael Phillipsa b Victoria Basa-Dalayc h Graham Bothamleyd i Renee N. Cataneoa j Phung Kim Lame k Maria Piedad R. Natividad f l Peter Schmittg m James Waia j a Menssana Research Inc. 1 Horizon Road Suite 1415 Fort Lee NJ 07024-6510 United States b Department of Medicine New York Medical College Valhalla NY United States c Tuberculosis Research Unit Angelo King Medical Research Center De La Salle Health Sciences Institute Cavite Philippines d Department of Respiratory Medicine Homerton University Hospital NHS Foundation Trust London E9 6SR England UK e Division of Pulmonary and Critical Care Medicine University of California San Diego 200 West Arbor Drive San Diego CA 92103-8374 USA f Center for Respiratory Medicine The University of Santo Tomas Hospital USTH Espana Boulevard Manila 1008 Philippines g Schmitt Associates 211 Warren St Newark NJ 07103 United States ARTICLE INFO s u M M A R y Article history Received 27 October 2009 Received in revised form 18 January 2010 Accepted 26 January 2010 Keywords Tuberculosis Breath Volatile Biomarker Diagnosis Background Volatile organic compounds VOCs in breath may contain biomarkers of active pulmonary tuberculosis derived from the infectious organism metabolites of Mycobacterium tuberculosis and from the infected host products of oxidative stress . Methods We analyzed breath VOCs in 226 symptomatic high-risk patients in USA Philippines and UK using gas chromatography mass spectroscopy. Diagnosis of disease was based on sputum culture smear microscopy chest radiography and clinical suspicion of tuberculosis CSTB . Chromatograms were converted to a series of 8 s overlapping time slices. Biomarkers of active pulmonary tuberculosis were identified with a Monte Carlo analysis of time-slice .

• Y học thường thức
• Characterisation
• Plant Responses
• Abiotic Stresses
• Importance of Genetic
• Manage Abiotic Stress
• Genetic Diversity
• Maize composites
• Morphological characterisation
• Corn (Zea mays L ) cultivars
• DUS characterisation of corn
• Fifteen descriptive characters
• Phenotypic characterisation
• Candida species
• Tertiary care teaching hospital hyderabad
• Phenotypic characterisation of Candida species
• Clinical isolates
• Hybrid nanocomposites
• The mechanical and microstructural characterisation
• Hybrid nanocomposites produced
• Stir and squeeze casting
• Microstructural characterisation
• García Esteban
• de Palacios
• Guindeo Casasús1
• García Fernández
• Characterisation of the xylem
• Characterisation of peeled veneer
• Plantation species in Vietnam
• Grade quality higher than D grade
• Acacia hybrid produced higher levels of large knot
• E
• urophylla plantations
• Petrophysical characterisation
• Pore system for a carbonate reservoir
• The HR structure
• Carbonate reservoir
• Ham Rong structure
• MB glass
• Melt quenching
• Radiation detection
• Radiation dosimeters
• Synthesis and characterisation
• Dysprosium doped borate glasses
• Functional characterisation
• Soybean galactinol synthase gene
• Various stress conditions
• Arabidopsis thaliana
• Phenotypic analysis
• Enterobacter aerogenes
• Bacillus thuringiensis
• Waste water in Egypt
• Molecular characterisation
• Malathion degrading bacterial strains
• Preparation of thematic maps
• Farming situation characterisation
• Distributary command area
• RS and GIS techniques
• GIS techniques
• Comparison of rate of isolation
• Characterisation of mycobacteria
• AFB Smear
• LJ Medium and MGIT
• Clinical suspicion
• Antibacterial properties
• Physicochemical property
• Disc diffusion technique
• Antibacterial characterisation
• Apis honey on gram positive human pathogens
• Tick resistance
• S100A8 expression
• Molecular characterisation of S100A8 Gene
• Rhipicephalus annulatus infestation
• Bos indicus
• BMC Plant Biology
• Arabidopsis SPL7
• Adapt plant growth
• DNA in vitro
• In vitro
• Physiological studies
• Alternaria leaf spot in cabbage
• Alternaria leaf spot
• Physiological characterisation
• Alternaria brassicicola
• SSR markers
• Molecular characterisation of DNA
• DNA of brown plant hopper biotypes
• Brown plant hopper biotypes
• Brown plant hopper resistance
• Various rice genotypes at gangavathi
• BMC Cancer
• Breast cancer
• Cell cycle
• Mechanisms underlying
• Taxane resistance
• Streptococcus suis
• Antibiotic resistance
• Partial characterisation
• Streptococcus suis bacteriophage
• Characterized lytic phage
• Crop residue
• Cow dung
• Integrated nutrient management
• Vermicompost produced from crop residue
• Vermicompost produced from cow dung
• Characterisation of vermicompost produced
• BMC Genomics
• Extracellular matrix
• Single cell prokaryotes
• Transcriptional characterisation
• Biological adhesion
• Nuclear energy
• Radiological characterisation
• D&D processes
• Dose rate measurements
• Total gamma measurements
• In situ gamma ray spectrometry
• Chromatography A
• Mechanical characterisation
• Chromatography media
• Agarose beads
• Dynamic mechanical analysis
• Master's thesis of Applied Science
• Master's thesis
• Characterisation of dosimetry
• Electron radiotherapy
• Bolus applications
• Modulated electron radiotherapy
• Clostridium perfringens
• 16S rRNA
• Multiplex PCR
• Clostridium perfringens type D isolated
• Characterisation of very strongly perfect graphs
• Very strongly perfect graphs
• Maximal complete sub graphs
• Barbell graph and friendship graph
• Even cycle of length