tailieunhanh - A rare case of pulmonary tuberculosis with simultaneous pulmonary and skin sarcoidosis: a case report

Tuberculosis and sarcoidosis are chronic diseases that rarely occur concomitantly. Sarcoidosis is a multisystem granulomatous disorder characterized pathologically by the presence of non-caseating granulomas in involved tissues. Tuberculosis is infectious disease caused by Mycobacterium tuberculosis characterized by granulomas with caseous necrosis. Case presentation: We present a case of 43-year-old female refugee from Kosovo with microbiological confirmation of pulmonary tuberculosis and pulmonary and skin sarcoidosis at the same time. Three weeks after corticosteroid therapy for pulmonary sarcoidosis was introduced, positive finding of mycobacterium culture of bronchial aspirate was observed. Based on these results, corticosteroid therapy was excluded and antituberculous therapy was introduced for six months. In the meantime, new. | Mise et al. Cases Journal 2010 3 24 http content 3 1 24 CASES JOURNAL CASE REPORT Open Access A rare case of pulmonary tuberculosis with simultaneous pulmonary and skin sarcoidosis a case report Kornelija Mise1 Ivana Goic-Barisic2 Neira Puizina-Ivic3 Igor Barisic4 Marija Tonkic2 Irena Peric1 Abstract Background Tuberculosis and sarcoidosis are chronic diseases that rarely occur concomitantly. Sarcoidosis is a multisystem granulomatous disorder characterized pathologically by the presence of non-caseating granulomas in involved tissues. Tuberculosis is infectious disease caused by Mycobacterium tuberculosis characterized by granulomas with caseous necrosis. Case presentation We present a case of 43-year-old female refugee from Kosovo with microbiological confirmation of pulmonary tuberculosis and pulmonary and skin sarcoidosis at the same time. Three weeks after corticosteroid therapy for pulmonary sarcoidosis was introduced positive finding of mycobacterium culture of bronchial aspirate was observed. Based on these results corticosteroid therapy was excluded and antituberculous therapy was introduced for six months. In the meantime new nodes on face and nose appeared and skin sarcoidosis was diagnosed. The patient was given corticosteroids and colchicine according to the skin and pulmonary sarcoidosis therapy recommendation. Conclusion The authors of this study suggest that in cases when there is a dilemma in diagnosis between tuberculosis and sarcoidosis we should advance with corticosteroid therapy until we have microbiological confirmation of mycobacterium culture. This case is remarkable because this is a third described case of sarcoidosis and tuberculosis together the first reported in Asia the second in South Africa and to authors knowledge this is a first case report in Europe. Background Tuberculosis and sarcoidosis are chronic granulomatous diseases. In many aspects they are similar although different. Tuberculosis is infectious .