tailieunhanh - Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts

We newly identified an association between the haplotype [A-G-(insertion)-T] and susceptibility to pulmonary TB (p = , false discovery rate q = ). TB patients with systemic symptoms had a lower -196 to -174 deletion/deletion genotype frequency than those without systemic symptoms ( vs. ; p = ). TB patients with the deletion/deletion genotype had higher blood NK cell counts than those carrying the insertion allele (526 vs. cells/μl, p = ). TB patients with pleuritis had a higher 1350 CC genotype frequency than those without pleuritis ( vs. ; p = ). TB patients with the 1350 CC genotype had higher blood NK cell. | Chen et al. BMC Medical Genetics 2010 11 17 http 1471-2350 11 17 BMC Medical Genetics RESEARCH ARTICLE Open Access Toll-like receptor 2 gene polymorphisms pulmonary tuberculosis and natural killer cell counts 1 2 3 111 Yung-Che Chen Chang-Chun Hsiao Chung-Jen Chen Chien-Hung Chin Shih-Feng Liu Chao-Chien Wu Hock-Liew Eng4 Tung-Ying Chao 1 Chia-Cheng Tsen1 Yi-Hsi Wang1 Meng-Chih Lin1 Abstract Background To investigate whether the toll-like receptor 2 polymorphisms could influence susceptibility to pulmonary TB its phenotypes and blood lymphocyte subsets. Methods A total of 368 subjects including 184 patients with pulmonary TB and 184 healthy controls were examined for TLR2 polymorphisms over locus -100 microsatellite guanine-thymine repeats -16934 T A -15607 A G -196 to -174 insertion deletion and 1350 T C . Eighty-six TB patients were examined to determine the peripheral blood lymphocyte subpopulations. Results We newly identified an association between the haplotype A-G- insertion -T and susceptibility to pulmonary TB p false discovery rate q . TB patients with systemic symptoms had a lower -196 to -174 deletion deletion genotype frequency than those without systemic symptoms vs. p . TB patients with the deletion deletion genotype had higher blood NK cell counts than those carrying the insertion allele 526 vs. cells gl p . TB patients with pleuritis had a higher 1350 CC genotype frequency than those without pleuritis vs. p . TB patients with the 1350 CC genotype had higher blood NK cell counts than those carrying the T allele 641 vs. 250 cells gl p . TB patients carrying homozygous short alleles for GT repeats had higher blood NK cell counts than those carrying one or no short allele 641 vs. 250 cells gl p . Conclusions TLR2 genetic polymorphisms influence susceptibility to pulmonary TB. TLR2 variants play a role in the development of TB phenotypes probably by controlling the .

• Y học thường thức
• Mineral Nutrition
• Root Absorption
• Soil Fungi
• Plant Interaction
• Plant Soil
• Microorganism Interactions
• Mineral nutrients
• Root growth
• Root development
• Root growth of crop plants
• Role of mineral nutrition
• Plant Cells
• Energy
• Enzymes
• Water Balance
• Plants
• Translocation
• Water and Solutes
• Genomic status
• Chemical and mineral composition
• Human nutrition
• Mineral composition
• Genomic groups grown in India
• Turkish Journal of Agriculture and Forestry
• Tạp chí Nông Lâm nghiệp
• Chromium toxicity in plants
• Chromosomal behavior
• Mineral nutrient status
• Plant growth and nutrition
• Microorganism Interaction
• Abiotic Stress
• Phytoremediation
• Biofortification
• Nanoparticles
• Plant Antioxidative
• Báo cáo lâm nghiệp hay
• cách trình bày báo cáo
• báo cáo lâm nghiệp
• công trình nghiên cứu lâm nghiệp
• tài liệu về lâm nghiệp