tailieunhanh - Cytologic Detection of Urothelial Lesions - part 7

Các tế bào trung tâm, giúp mở rộng với tỷ lệ NC rất cao, là một polyoma nguyên mẫu tế bào bị nhiễm virus với kính mặt đất và margination hạt nhân của chất nhiễm sắc. Tuy nhiên, trong phần còn lại của lĩnh vực này là một loạt các tế bào ác tính | 110 3. Grading Urothelial Neoplasms Figure . High Grade Urothelial Carcinoma with Polyoma Virus infected cells voided urine The central cell greatly enlarged with very high NC ratio is a prototypical polyoma virus infected cell with ground glass nucleus and margination of the chromatin. However in the rest of the field are a variety of malignant cells from a high grade urothelial carcinoma. Compare the nucleus of the polyoma virus infected cell with the irregular nuclear shapes of the carcinoma cells. 600x Mimics of High Grade Urothelial Carcinoma 111 Figure . Polyoma Virus voided urine The ground glass nucleus is unusual by virtue of the light staining marginated chromatin. The high NC ratio round nuclear shape and generalized cellular enlargement is distinctly different from the smaller basal cell directly above the infected cell. Other squamous and urothelial cells surround the decoy cell. 600x 112 3. Grading Urothelial Neoplasms Figure . Polyoma Virus voided urine Features supporting polyoma virus infection are the enlarged cell and round nucleus with a smooth border. This cell is not entirely characteristic as there is only partial ground glass dissolution of the nuclear chromatin leaving remnants of the nuclear matrix and a prominent nucleolus. It may be a high grade urothelial carcinoma cell. Close follow-up of patients with such cellular changes is definitely warranted. 600x